One of the best understood examples of this tumor cell biology is found in colorectal carcinoma cells. Colon cancer cells frequently express a mutated K-RAS protein, an autocrine-activated EGF receptor or a mutant B-RAF protein [1,2]. Downstream activation of the PI3K/AKT and ERK1/2 ...
The tumor microenvironment is a complex space comprised of normal, cancer and immune cells. The macrophages are considered as the most abundant immune cells in tumor microenvironment and their function in tumorigenesis is interesting. Macrophages can be present as M1 and M2 polarization that show anti...
drug resistance remains challenging. Cancer stem cells (CSCs) are self-renewing and differentiate into cancer tissues with tumor heterogeneity. CSCs are associated with the progression of breast, colon, and lung cancers. Hence, recent studies have focused on the role of CSCs in resistance to anti-...
Tumor and stem cell biology transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development Cancer Res, 70 (14) (2010), pp. 6071-6082, 10.1158/0008-5472.CAN-09-4442 View in ScopusGoogle Scholar 79 T. Yoshimasu, T. Sakurai, S. Oura, et al....
Cell Rep. 2012;1:191–9. CAS PubMed Google Scholar Yeh YW, Cheng CC, Yang ST, Tseng CF, Chang TY, Tsai SY, et al. Targeting the VEGF-C/VEGFR3 axis suppresses Slug-mediated cancer metastasis and stemness via inhibition of KRAS/YAP1 signaling. Oncotarget. 2017;8:5603–18. PubMed ...
Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological reconfiguration via multiple
In recent years, the biological role of changes in physical factors in carcinogenesis and progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is a critical physical factor of tumor microenvironment and remains alte
Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer. Key Words: Cancer stem cells; Stem cell; Plasticity; Tumor hierarchy; Microenvironment; Immune-mediated therapies; ...
chemoresistance, metastasis, and recurrence. The implementation of cancer stem cell therapies may potentially augment the tumor cells’ sensitivity to existing chemotherapy protocols, thereby mitigating the risks of tumor metastasis and recurrence, and ultimately improving the survival rates of ovarian cancer...
In the last few decades, the role of cancer stem cells in initiating tumors, metastasis, invasion, and resistance to therapies has been recognized as a potential target for tumor therapy. Understanding the mechanisms by which CSCs contribute to cancer progression can help to provide novel therapeuti...