Initial susceptibility testing should be done in persons known to be at high risk. These include patients with a history of antituberculous chemotherapy; patients in a geographic region in which there is a high prevalence of drug resistance, such as Asia, Africa, and Latin America; and contacts...
Pregnancy provides an opportunity to screen for TB; all pregnant women can undergo tuberculin skin testing. If the results are positive, chest radiography can be performed with lead shielding. Chest radiography should not be delayed during the first 3 months of pregnancy in patients with suggestive...
“People think it’s just antibiotics and testing, but people infected with the disease need more than that — they need good living conditions, nutrition, and access to sanitation,” Koch recently told me on the phone. Eradicating tuberculosis globally can’t happen without better TB drugs, an...
Important considerations in SOT candidates are clinical evaluation of latent tuberculosis infection (LTBI) with the tuberculin skin testing (TST) and/or interferon gamma release assays (IGRAs), the utility of routine screening chest x-rays (CXR), and LTBI treatment regimens (especially in liver tran...
Combating the spread of drug resistant tuberculosis is a global health priority. Whole genome association studies are being applied to identify genetic determinants of resistance to anti-tuberculosis drugs. Protein structure and interaction modelling are
and now only a single prediction target can be achieved by any in silico vaccine design technology for effective vaccine development16. For us to quickly determine the top vaccine components for additional development and testing, no method available today is capable of simultaneously making many pred...
The first large-scale study demonstrating how phenotypic testing can be replaced by WGS for first-line drug testing. Google Scholar Gardy, J. L. et al. Whole-genome sequencing and social-network analysis of a tuberculosis outbreak. N. Engl. J. Med. 364, 730–739 (2011). CAS PubMed ...
Testing everyone with TB signs and symptoms would cost almost US$0.47 billion/year globally, much more than conventional diagnostics. However, in European countries, Brazil and South Africa the cost would represent <10% of overall TB funding. The authors concluded that while using it to test eve...
models, the RS ratio should accelerate selection of regimens for human testing. The central challenge to shortening TB treatment is eliminating the drug-tolerant persister population that withstands the initial rapid killing phase. Genetically drug-susceptible bacterial populations that have survived ...
The Rwandan strain was isolated from a male patient, aged 77 years, HIV-negative, resident of Rulindo district bordering with the Southwest of Uganda, and who had lived in Uganda previously. The patient was diagnosed with rifampicin-resistant TB based on standard Xpert MTB/RIF testing (Xpert;...