The first large-scale study demonstrating how phenotypic testing can be replaced by WGS for first-line drug testing. Google Scholar Gardy, J. L. et al. Whole-genome sequencing and social-network analysis of a tuberculosis outbreak. N. Engl. J. Med. 364, 730–739 (2011). CAS PubMed ...
A recent theory has postulated a continuum spectrum of tuberculous pleurisy, suggesting that TB empyema are predominant in lymphocytes during initial testing. However, the fluid becomes predominantly neutrophilic as the disease progresses, along with the development of loculations and positive spill cultur...
The recombinant Bacille Calmette-Guérin vaccine VPM1002: ready for clinical efficacy testing Front Immunol, 8 (2017), p. 1147 View in ScopusGoogle Scholar 48 A.G. Loxton, J.K. Knaul, L. Grode, A. Gutschmidt, C. Meller, B. Eisele, et al. Safety and immunogenicity of the recombinant ...
However, in South Africa, the impact of the 2020 national COVID-19 lockdown on HIV testing and treatment in KwaZulu-Natal, where 1•7 million people are living with HIV, showed that ART treatment provision was generally maintained during the lockdown, but HIV testing and ART initiations ...
The in vitro susceptibility testing of pyrazinamide is technically challenging and often unreliable due to well-known problems (size of the test inoculum, no growth of some strains in drug-free tube under acidic conditions etc.) recognized in previous studies [47,48,49]. Phenotypic DST results ...
However, such testing has not been routinely required in adjacent counties in the AF zone where bTB is either endemic, or at least periodically present, in wild deer at very low prevalence. Slaughter surveillance, while more cost effective, may not detect infected herds until several years after...
This is followed by further Mtb specific tests or drug susceptibility testing (i.e. nucleic acid amplification tests such as the Gene Xpert MTB/RIF [4]). Diagnosis of TB in most low- and middle-income countries continues to rely on sputum smear microscopy for acid-fast bacilli (Ziel-...
Abbreviations CPHL: Central Public Health Laboratory; DR-TB: Drug resistant tuberculosis; DST: Drug susceptibility testing; HIV: Human immunodeficiency virus; HRESZ: H = isoniazid R = rifampicin E = ethambutol S = streptomycin Z = pyrazina- mide; HPD: Highest posterior ...
The shorter all-oral BDQ-containing regimen is recommended in patients with MDR-TB (with at least confirmed RIF resistance) who fulfill the following eligibility criteria: (1) resistance to fluoroquinolones has been excluded as fluoroquinolones susceptibility testing needs to be undertaken before the ...
This is followed by further Mtb specific tests or drug susceptibility testing (i.e. nucleic acid amplification tests such as the Gene Xpert MTB/RIF [4]). Diagnosis of TB in most low- and middle-income countries continues to rely on sputum smear microscopy for acid-fast bacilli (Ziel-...