Methods At the Sainte-Anne Hospital, a referral centre for psychiatric patients throughout the municipal region of Paris, IGRA screening is performed during pre-employment and general health examination or after potential contact to MTB. The QuantiFERON Gold in tube (QFT) is used and data on TB...
There have been significant advances in the development of genetic tools for studyingM. tuberculosis, which include mutant screening and genome editing methods[14,15]. Such technologies have significantly enhanced our understanding of the molecular basis of pathogenesis and have paved the way f...
Screening methods for TB include the following: Mantoux tuberculin skin testwith purified protein derivative (PPD) for active or latent infection (primary method) In vitro, blood test based on interferon-gamma release assay (IGRA) with antigens specific for Mycobacterium tuberculosis for latent infec...
The WHO has recommended the use of either TST or IGRA for screening at- risk children who reside in countries with a low burden of dis- ease where there are ample resources for performing both tests (12). Other immunologic assays, such as interferon-inducible protein 10 (IP-10), continue...
Objective To explore the application effect of TB-IGRA combined with other detection methods in tuberculosis screening. Methods 795 patients admitted in our hospital from January to August 2017 were divided into tuberculosis group and non-tuberculosis group according to the condition. All patients were...
Screening for latent tuberculosis infection is mandatory before starting anti-tumor necrosis factor therapy. New assays based on interferon-纬 (IFN-纬) release have recently become available and may be more accurate. The aim of this stud... M. McGuinn,B. Schmitt,A. Harris,... - 《Infection...
Ethical approval was not needed because the study used fully anonymised observational data that were obtained as part of an assessment of routine clinical service. Screening and management We first screened immigrants who attended the centres with a symptom questionnaire followed by one-step IGRA (...
IGRA done as a screening test or during contact investigation Suspicion for TB is higher in patients who have fever, cough lasting > 2 to 3 weeks, night sweats, weight loss, and/or lymphadenopathy and in patients with possible TB exposure (eg, via infectious family members, friends, or othe...
Laboratory confirmation of the etiological agent by direct screening and culture for AFB, PPD (purified protein derivative), histopathological analysis, interferon-gamma release assay (IGRA) and polymerase chain reaction (PCR) for BK. Differential diagnosis It must be established with NTM, syphilis, ba...
pertinent studies on this topic will become more feasible. Nevertheless, whichever method of screening is chosen, whether it be the TST, an IGRA or both, taking into consideration risk factors on a case by case basis is key; this will optimize the risk/benefit of the therapies currently avail...