Mechanism of Action of Tetrodotoxin (TTX) and Saxitoxin (STX)Marine toxins such as TTX and STX have aroused the interest of physiologists, biochemists, pharmacologists, and biological warfare people, as well as writers of spy and mystery stories. In the hands of the neuroscientist they have ...
Recent advances in the study of mechanism of action of marine neurotoxins T. Narahashi, et al.Neurotoxicology 15 545 (1994) Hille, B. (2001) Ion Channels in Excitable Membranes (Third Edition) Chapter 3. 北京联立信生物技术有限公司 订购电话:4000-866-908,010-51143668 ...
Unlike calcium current, TTX-resistant sodium current is not accompanied by opposing calcium-activated potassium current and may provide an effective mechanism by which the duration of action potentials (and consequently calcium entry) can be regulated. 展开 ...
Unlike calcium current, TTX-resistant sodium current is not accompanied by opposing calcium-activated potassium current and may provide an effective mechanism by which the duration of action potentials (and consequently calcium entry) can be regulated....
The ionic mechanism underlying the shortening of the action potential and the reduction in pacemaker activity by lidocaine, quinidine, and procainamide in ... E Carmeliet,T Saikawa - 《Circulation Research》 被引量: 295发表: 1982年 Slow inactivation of the sodium current in rabbit cardiac Purkinje...
再通过关闭机制(gating mechanism)使通道关闭,河豚毒素作用于毒素受体(rtox),可使h闸门(h—gate)关闭,阻滞钠离子通过细胞膜,使细胞膜失去极化状态,从而抑制甚至阻断了神经一肌肉的传导过程,导致神经肌肉活动障碍,严重者可发生麻痹状态。类似箭毒样作用,最后可引起呼吸中枢麻痹使呼吸停止,血管中枢麻痹,可引起血压下降,...
An alternative transduction mechanism excluding ion channels is that the pressure-induced displacement of the lipid bi-layer generates action potentials24. By extending the Hodgkin and Huxley model to include capacitance changes in the cell membrane due to ultrasound, Plaksin et al. created a model25...
The mechanism underlying the extracellular Ca2+ effec... TR Chay - 《Biophysical Journal》 被引量: 107发表: 1997年 Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons Nociceptive sensory neurons ...
of unique subset of myelinated Ah-type VANs including baroreceptor neurons that is mainly seen in females with lower pressure-discharge threshold [6,7], which then elevates the parasympathetic drive and concomitant reduction in the activity of sympathetic pathway [8,9] through baroreflex mechanism....
toblocktheef.fectof SP. b) CellularmechanismofNK一1 111ee虢ctofS扑SPwaSalso abolishedby me antagoIlist ofG protein,GDP—D—s(1 mM i11tracellul∽,tlle iI皿bitorsof PKC,BIM(1肛M)andChel.C(5斗M)and t11e PKC￡specificinhibitor,￡V1-2(200pM,intracellul神,but ...