All physicians who administer methotrexate must understand its mechanism of action, distribution, and elimination to minimize potential risks to the patient. CASE: A young, dialysis-dependent woman received a standard dose of methotrexate for an ectopic pregnancy. Prolonged methotrexate exposure resulted....
Mechanism of Action Immunosuppressants Orphan Drug Status Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases. No New Molecular Entity No Highest Development Phases Phase I Type 1 diabetes mellitus Most Recent Events 14 Apr 2023 M...
The dose will vary between patients depending on their disease activity and the decision of their prescribing physician.The exact mechanism of action of methotrexate remains unclear but it acts as a folate antagonist. Therefore all patients receiving methotrexate receive 5mg/week of oral folic acid ...
Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines Determinants of methotrexate (MTX) resistance in cell lines resistant to short, but not continuous, MTX exposure were investigated since such lines may have relevance to clinical...
The stream throughput is too big and the stream can't be sent correctly with the UDP transport. UDP is more performant, faster and more efficient than TCP, but doesn't have a retransmission mechanism, that is needed in case of streams that need a large bandwidth. A solution consists in ...
These data provide additional insights into differences in the mechanism of action of anti-TNFs and abatacept, and imply an effect of T-cell co-stimulation blockade on B-cell function and autoantibody production. References Disclosure of Interest M. H. Buch Grant/research support from: Pfizer, ...
The stream throughput is too big and the stream can't be transmitted correctly with the UDP transport protocol. UDP is more performant, faster and more efficient than TCP, but doesn't have a retransmission mechanism, that is needed in case of streams that need a large bandwidth. A solution...
One of the possible explanations is that MTX interacts with a non-voltage-gated and usually inactive channel presumably belonging to the ion channel superfamily, through which the alkylamines block ion entry by the mechanism similar to that proposed for K+ channels. 展开 ...
The stream throughput is too big and the stream can't be sent correctly with the UDP transport. UDP is more performant, faster and more efficient than TCP, but doesn't have a retransmission mechanism, that is needed in case of streams that need a large bandwidth. A solution consists in ...
Methotrexate (MTX) is one of the most active and widely used agents for the treatment of acute lymphoblastic leukemia (ALL). To elucidate the mechanism for... VM Belkov,EY Krynetski,JD Schuetz,... - 《Blood》 被引量: 1403发表: 1999年 Pharmacokinetics and Pharmacodynamics of Methotrexate in...