Part of MTX action mechanism in which thymidylate synthase (TS) is involved (A).Aurea, LimaVítor, SeabraMiguel, BernardesRita, AzevedoHugo, SousaRui, Medeiros
Mechanism of ActionImmunosuppressants Orphan Drug Status Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases. No New Molecular EntityNo Highest Development Phases Phase IType 1 diabetes mellitus ...
The present study examines the apoptosis-inducing activity and the underlying mechanism of action of quercetin in a methotrexate (MTX)-resistant osteosarcoma model. Our results showed that quercetin inhibited cell viability in a dose-dependent manner and there was no cross-resistance between MTX and ...
The stream throughput is too big and the stream can't be sent correctly with the UDP transport. UDP is more performant, faster and more efficient than TCP, but doesn't have a retransmission mechanism, that is needed in case of streams that need a large bandwidth. A solution consists in ...
One of the possible explanations is that MTX interacts with a non-voltage-gated and usually inactive channel presumably belonging to the ion channel superfamily, through which the alkylamines block ion entry by the mechanism similar to that proposed for K+ channels. 展开 ...
Proteomic Studies on the Mechanism of Cytotoxicity Induced by Shikonin in JAR/MTX Cells 紫草素对JAR/MTX细胞毒性作用机制的蛋白质组学研究 2. The Effect of Shikonin on Reversing Drug-resistance of Choriocarcinoma JAR/MTX Cells and the Expression of MRP and LRP 紫草素对绒癌JAR/MTX细胞的耐药逆转...
The stream throughput is too big and the stream can't be transmitted correctly with the UDP transport protocol. UDP is more performant, faster and more efficient than TCP, but doesn't have a retransmission mechanism, that is needed in case of streams that need a large bandwidth. A solution...
Competitive exclusion and adhesion are two of the most effective methods used to block pathogen colonisation, with an added benefit of enhancement of the epithelial barrier [34,35,36,37]. Secretion of antimicrobial substances is another major mechanism, with bacterial fermentation leading to the ...
toxins Article Modulation of Mucin (MUC2, MUC5AC and MUC5B) mRNA Expression and Protein Production and Secretion in Caco-2/HT29-MTX Co-Cultures Following Exposure to Individual and Combined Aflatoxin M1 and Ochratoxin A Xin Huang 1,2,3,4,†, Yanan Gao 1,2,3,4,†, Songli Li 1,2...
A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an or . Receptor sites have specific affinities for drugs based on the chemical structure of the drug, as well as th...