CC-671 是一种双重TTK蛋白激酶/CDC2样激酶(CLK2)抑制剂,对TTK和CLK2的半数抑制浓度(IC50值)分别为0.005 μM和0.006 μM。 产品性质 英文别名 (English Synonym) CC-671 中文名称 (Chinese Name) / 靶点 (Target) CLK2 TTK 通路 (Pathway) Cell Cycle/DNA Damage CAS号 (CAS NO.) 1618658-88-0...
DNA損傷反應 MDM2hMps1Histone H2B ubiquitinationoxidative stressDNA damage responseMDM2 is an E3 ubiquitin ligase that targets proteins involved in cell cycle progression. Although many MDM2 substrates have been identified, how its activity is regulated is not fully understood, especially when cells are ...
B. et al. Targeting MPS1 enhances radiosensitization of human glioblastoma by modulating DNA repair proteins. Mol. Cancer Res. 13, 852–862 (2015). Article PubMed PubMed Central CAS Google Scholar Miao, R. et al. Utility of the dual-specificity protein kinase TTK as a therapeutic target ...
DNA damage, as assessed by western blot analyses using phospho-specific antibodies, did not reveal increased phosphorylation levels of the ATR/p53 targets H2AX and Chk1 after TTK silencing. Likewise, cellular Cyclin B1 levels were also not systematically altered (B). UV-treated cancer cells ('UV...
ttk sirna i #6367 (+) or signalsilence?ttk sirna ii (+), using ttk (d15b7) rabbit mab #5469 (upper) or α-tubulin (11h10) rabbit mab #2125 (lower). the ttk (d15b7) rabbit mab confirms silencing of ttk expression, while the α-tubulin (11h10) rabbit mab is used as a ...
DNA-DAMAGEANEUPLOIDYINTERFERONCANCERPROGRESSIONMECHANISMSPACLITAXELDespite substantial recent advances in treatment, multiple myeloma (MM) remains an incurable disease, with a shortage of treatment options for patients with high -risk disease, warranting the need for novel therapeutic targets and treatment ...