The Cost-Benefit Analysis of Using a Staffing Firm vs. In-House Recruitment October 12th, 2024| Your Content Goes Here In today’s dynamic and rapidly changing business environment, finding the right talent is critical for the success of any [...] ...
Here, we overcome a high degree of continuous conformational heterogeneity to determine the 2.8- cryo-electron microscopy (cryo-EM) structure of the complete human TSC in complex with the lysosomal recruitment factor WD repeat domain phosphoinositide-interacting protein 3 (WIPI3). We discover a ...
with changes to either affecting its activity [25]. Post-translational modifications (PTMs) regulate this complex, primarily within the PI3K/ AKT pathway. Growth factors activate PI3K, leading to PIP3 synthesis and the recruitment of PKD and AKT to the plasma membrane (Fig.1B) [26]...
In post-mitotic neurons, Tsc1/2-mTORC1 signaling controls neuronal communication in a cell type-specific manner via regulation of membrane excitability, synaptic transmission, and synaptic plasticity6,7,8,9,10,11,12,13,14,15. Loss-of-function mutations in negative regulators of mTORC1 cause neu...
Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity 38, 729–741 (2013). Article CAS PubMed Google Scholar Ma, Y., Pitt, J. M., Li, Q. & Yang, H. The renaissance of anti-neoplastic immunity from tumor cell demise. Immunol. Rev...
By observing binary protein interactions using coimmunoprecipitation, we discovered that the composition of TORC2 and its recruitment of the downstream effectors Slm1p and Slm2p were differentially affected in different avo3(ts) mutants. These molecular defects can be corrected only by expressing AVO3...
HEK293FT cells transfected with siRNAs targeting components of the GATOR1 complex DEPDC5 and NPRL2, required for the Rag proteins to become inactive upon amino acid removal, show impaired lysosomal recruitment of TSC2 upon amino acid removal, compared to cells treated with control siRNAs. TSC2 ...
In addition, angiotensin II promotes the expression of cell adhesion molecules by activating oxidative stress, and induces the synthesis of pro-inflammatory cytokines and growth factors, which leads to increased vascular permeability, leukocyte recruitment and vascular fibrosis, and ultimately leads to ...
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Communications Biology(2024) Advertisement Nature Communications(Nat Commun) ISSN2041-1723(online) Sign up for theNature Briefing: Cancernewsletter — what matters in cancer research, free to your inbox weekly. Email address Sign up I agree my information will be processed in accordance with theNatur...