[2]and in mast cells cultured from progenitors inumbilical cord bloodof normal individuals or in peripheral blood of asthmatics[6]. Immunohistochemical light and immuno-goldelectron microscopytechniques localize γ-tryptase to intracellular granules in resting mast cells[1,2]; furthermore, fluorescence...
Blood was taken for tryptase measurement on each test day before and after drug challenge, and the changes in serum tryptase levels in patients with no reactions were compared with those who experienced immediate reactions to a drug. Results: Thirty-four of 785 drug provocations were clinically ...
Results The migratory capacity of HFL-1 cells was enhanced by blood-derived mast cells (p < 0.02), LAD2 cells (p < 0.001), conditioned medium (p < 0.05) and tryptase (p < 0.006). P2pal-18S decreased the induced migration caused by mast cells (p < 0.001) and...
Serine proteases play important roles in embryonic development, immunity, blood coagulation, fertilization, fibrinolysis, hormone activation, food digestion, and other biological processes. Six gene clusters have been identified in the human genome that contain four or more serine protease genes at chromos...
experimental COPD and accumulation of pulmonary mast cells in mice. Lastly,TLR7mRNA is increased in pre-existing datasets from patients with COPD, while TLR7+mast cells are increased in COPD lungs and associated with severity of COPD. Our results thus support roles for TLR7 in mediating emphysema...
Rabenhorst, A. et al. Mast cells play a protumorigenic role in primary cutaneous lymphoma.Blood120, 2042–2054 (2012). ArticleCASGoogle Scholar Soucek, L. et al. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors.Nat. Med.13, 1211–1218 ...
Nasal delivery allows the passage of the compound to the blood stream directly after administering the therapeutic product to the nose, without the necessity for deposition of the product in the lung. Formulations for nasal delivery include those with dextran or cyclodextran. Transdermal Delivery ...
To isolate the antibodies, the IgG fraction of the blood serum (or from egg yolks in the case of avians) is isolated in standard fashion. With egg yolks, this can be accomplished utilizing a commercial product such as Promega Corporation's "EGGstract" TM IgY Purification System (Promega Corp...
In addition, blood samples acquired by different techniques should not be mixed together and should be analyzed separately if possible.doi:10.1007/s00414-017-1738-8Tse, R.Garland, J.Kesha, K.Elstub, H.Cala, A. D.Ahn, Y.Stables, S....
An “isolated” polypeptide or protein is a polypeptide or protein that is found in a condition other than its native environment, such as apart from blood and animal tissue. In a preferred form, the isolated polypeptide is substantially free of other polypeptides, particularly other polypeptides ...