Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes. Pigment Cell Melanoma Res. 2013;26(3):348–356. Clinical Ophthalmology Publish your work in this journal Clinical Ophthalmology is an international, peer-reviewed journal...
Further, TRPV1 inhibited M1 macrophage polarization via the Ca2+/calcium/calmodulin-dependent protein kinase II/nuclear factor-erythroid 2-related factor 2 (Ca2+/CaMKII/Nrf2) signaling pathway. These findings suggest that TRPV1 is a novel therapeutic target reducing synovitis and alleviating OA. ...
Calcium appears to play a major role in this form of short-term plasticity. Finally, recent evidence suggests that the gain of this synapse is additionally regulated by ambient light levels. Both cyclic guanosine monophosphate ( cGMP )/protein kinase G (PKG) and protein kinase C (PKC) appear...
We also provided voltage ramps to monitor changes in the slope conductance; this was computed in the linear range between − 95 mV and − 65 mV (to avoid contributions from the voltage-activated L-type calcium channel) (Fig. 1C). In control experiments (with only basic ...
Night vision requires signaling from rod photoreceptors to adjacent bipolar cells in the retina. Mutations in the genes NYX and GRM6, expressed in ON bipolar cells, lead to a disruption of the ON bipolar cell response. This dysfunction is present in patients with complete X-linked and autosomal...
Functionally, Trpm1 is activated as a part of a signaling cascade that is initiated by the metabotropic glutamate receptor, mGluR6 (Irie and Furukawa, 2014; Koike et al., 2010b; Morgans et al., 2009). Loss of function mutations in Trpm1 result in early age myopia and congenital ...
Transient receptor potential melastatin-1 (TRPM1) is a calcium channel that is essential for the depolarization of photo-responsive retinal bipolar cells, but most of the physiological functions and cellular roles of this channel are still poorly understood. Most transient receptor potential (TRP) ...