[4]Sonja, Kilo, and, et al. Peripheral CGRP release as a marker for neurogenic inflammation: a model system for the study of neuropeptide secretion in rat paw skin[J]. Pain, 1997. [5] Mcnamara C R , Mandel-Brehm J , Bautista D M , et al. TRPA1 mediates formalin-induced pain[J]...
Transient receptor potential ankyrin 1(TRPA1) is a key player in pain and neurogenic inflammation, and is localized in nociceptive primary sensory dorsal root ganglion(DRG) neurons. TRPA1 plays a major role in the transmission of nociceptive sensory signals. The generation of neurogenic inflammation...
The present review discusses the relationship between TRPA1 and neurogenic inflammation in asthma, hoping to enhance our understanding of the mechanisms of airway inflammation in asthma. 展开 关键词: Asthma Nerve Fibers, Unmyelinated Neurogenic Inflammation Transient Receptor Potential Channels ...
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins Victor Meseguer, Yeranddy A. Alpizar, Enoch Luis, Sendoa Tajada, Bristol Denlinger, Otto Fajardo, Jan-Albert Manenschijn, Carlos Fernández-Peña, Arturo Talavera, Tatiana Kichko, Belén Na...
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1[J]. Proc Natl Acad Sci U S A, 2007, 104(33): 13519 -13524. 12. Matta JA, Cornett PM, Miyares RL, et al. General anesthetics activate a nociceptive ion ...
Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in the skin by the release of neuropeptides from sensory nerve ending
Moreover, we find that pain and acute vascular reactions, including neurogenic inflammation (CGRP release) caused by LPS are primarily dependent on TRPA1 channel activation in nociceptive sensory neurons, and develop independently of TLR4 activation. The identification of TRPA1 as a molecular ...
Andre E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R (2008) Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the T...
We thereforeinvestigated the effects of three carotenoids (β-carotene,lutein and lycopene) on cutaneous neurogenic inflammation.Acute neurogenic edema and inflammatory cell recruitmentwere induced by smearing the TRPA1 agonist mustard oil(5 %) or the TRPV1 activator capsaicin (2.5 %) on the mouse...
By “inflammatory component of atopic dermatitis”, it is meant an inflammation involving CD4+ lymphocytes, eosinophils, mast cells and Th2 cytokines. The inflammatory component of atopic dermatitis does not involve, and is different from, neurogenic inflammation (or neurogenic flare response). Indeed...