First, the inflammatory factors released after inflammation interacts with TRPA1 to promote inflammatory response; second, TRPA1 regulates the function of immune cells such as macrophages and T cells, In addition, it has anti-inflammatory and antioxidant effects in some inflammatory diseases. Third...
TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis. J. Neurosci. 33, ... E.,S.,Schwartz,... - 《Journal of Neuroscience》 被引量: 143发表: 2013年 Synergistic Role of TRPV1 and TRPA1 in Pancreatic Pain and Inflammation ...
The transient receptor potential channel subtypes V1 (TRPV1) and A1 (TRPA1) play a critical role in the development of hyperalgesia in inflammatory pain mo... NB Ruparel,AM Patwardhan,AN Akopian,... - 《Pain》 被引量: 266发表: 2008年 The involvement of TRPA1 channel activation in the...
TRPA1 (Transient Receptor Potential Ankyrin 1) channels are believed to play a significant role in the development and progression of asthma pathology [11]. The activation of TRPA1 channels has been demonstrated to induce bronchoconstriction, airway inflammation, and airway hypersensitivity in asthma ...
How- ever, whether 20-HETE via activation of TRPV1 is a pivotal ligand for the channel in the setting of inflammation is unknown. Although many more potential lipid mediators have been identified at such sites of inflammation, the exact role of 20-HETE remains uncertain. In this study, we...
We determined whether TRPV1 plays a role in inflammatory signaling cascades in the brain. STAT3 is a well-known marker of proinflammatory responses in the brain27,34. The activation of STAT3 may be detected by the phosphorylation of STAT3 and its subsequent nuclear translocation36. We previously...
The results indicate that CGRP, which is probably released from the peripheral endings of cutaneous primary afferents, plays a role in the inflammatory response to mustard oil, but not carrageenin.Access through your organization Check access to the full text by signing in through your organization...
Christophe AltierUniversity of CalgaryChannelsLapointe TK , Altier C . 2011 . The role of TRPA1 in visceral inflammation and pain . Channels 5 : 525 – 529 .T.K. Lapointe, C. Altier, The role of TRPA1 in visceral inflammation and pain, Channels (Austin) 5 (November 1 (6)) (2011)....
Lapointe T.K., Altier C. The role of TRPA1 in visceral inflammation and pain. Channels. 2011; 5 :525–529. doi: 10.4161/chan.5.6.18016. [ Cross Ref ]Lapointe T. K., Altier C. (2011). The role of TRPA1 in visceral inflammation and pain . Channels (Austin) 5 , 525–529. ...
We next asked whether TRPC4 in DRG neurons plays a predominant role in chronic itch and more specifically in psoriasis because this channel (i) is expressed in TRPV1-positive DRG neurons, which contribute to psoriasiform skin inflammation and chronic itch in the mouse model of IMQ-induced psor...