tRNAPROCESSING,RNasePANDRIBOZYMES 1.2.3.4.tRNAprocessinginprokaryotestRNAprocessingineukaryotesRNasePRibozymes 1.tRNAprocessinginprokaryotes •大肠杆菌tRNA操纵子中包含tRNA的编码区域；•还包括多至7种tRNA基因的操纵子 MaturetRNAsaregeneratedbyprocessinglongerpre-tRNAtranscripts,whichinvolves1.specificexo-and...
Pre-tRNA and Pre-rRNA Processing in EukaryotesHendrik A. RauéELSEVIEREncyclopedia of Biological ChemistryKushner, S. R. 2004. Pre-tRNA and pre-rRNA processing in bacteria. Encycl. Biol. Chem. 3:420-424.
P. Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. J. Biol. Chem. 284, 18218–18227 (2009). CAS PubMed PubMed Central Google Scholar Rakovich, T. et al. Queuosine deficiency in eukaryotes compromises tyrosine production through increased ...
Structural basis for stop codon recognition in eukaryotes. Nature 524, 493–496 (2015). Article CAS PubMed PubMed Central Google Scholar Crick, F. H. Codon–anticodon pairing: the wobble hypothesis. J. Mol. Biol. 19, 548–555 (1966). Article CAS PubMed Google Scholar Dittmar, K. A...
eukaryotes, hindering the identification of a general underlying mechanism behind that phenotypic diversity. Here, through bioinformatics analysis of representative eukaryotic genomes we have predicted: i) the genes enriched in NAU codons, whose translation would be affected by tRNA Q-modification (Q-...
Stress induces tRNA cleavage by angiogenin in mamma lian cells. FEBS lett, 2008, doi: 10.1016/jfebslet.2008.12.043 37 Thompson D M, Lu C, Green P J, et al. tRNA cleavage is a conserved response to oxidative stress in eukaryotes. RNA, 2008, 14(10): 2095—2103[DOI] 38 Adam R D....
The function of tRNA modifications in B-cell responses is not known. N7-methylguanosine (m7G) is one of the most prevalent tRNA modifications, and it is highly conserved in prokaryotes, eukaryotes, and some archaea18. In humans, m7G modification is catalyzed by the METTL1/WD repeat domain 4...
In eukaryotes, the presence of at least 2 different translationally-active and membrane-separated compartments, the cytosol and mitochondria, makes already the situation more complex with respect to the number of aaRSs that these organisms have to possess; and becomes even more complicated if the or...
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In eukaryotes, tRNAs are transcribed as precursor transcripts (pre-tRNAs). While pre-tRNA processing is initiated in the nucleus, the cellular path towards mature tRNAs takes place at different subcellular locations. The complex dynamics between nuclear and cytoplasmic tRNA processing as well as the ...