To understand the role of tRNA in protein synthesis, we can break down the process into several key steps:1. Transcription of DNA to mRNA: The process of protein synthesis begins with the transcription of DNA into messenger RNA
Macromolecular interactions in protein synthesis: the interaction of tRNA with its biological partners (aminoacyl-tRNA synthetase, elongation factor EF-Tu, Ribosome)food problemfive kinds of integration (wutongyirural reformXinjiang Uygur Autonomous Region...
2 Pan, T. Modifications and functional genomics of human transfer RNA.Cell Res28, 395-404, doi:10.1038/s41422-018-0013-y (2018). 3 Schimmel, P. The emerging complexity of the tRNA world: mammalian tRNAs beyond pr...
[12] Marshall L, et al. Elevated tRNA(iMet) synthesis can drive cell proliferation and oncogenic transformation. Cell 133, 78-89. (2008), PMID:18394991. [13] Krokowski D, et al. A self-defeating anabolic program leads to beta-cell apoptosis in endoplasmic reticulum stress-induced diabetes...
Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their therapeutic potential for the treatment of genetic diseases — primarily those associated with a mutation altering mRNA translation — has gained significant attention. Engineering tRNAs to readthrough nonsense ...
Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post-transcriptionally. A wide variety of tRNA modifications are found in the tRNA
protein gene expressionprotein synthesis factorsribosomal protein genesribosomessminoacyl‐transfer RNA synthetasestransfer RNA synthesisdoi:10.1128/9781555817992.ch22Tina M. HenkinJohn Wiley & Sons, LtdHenkin, T. M. 2002. Ribosomes, protein synthesis factors, and tRNA syn- thetases, p. 313-322. ...
近日,美国罗切斯特大学Aab心血管研究所姚鹏博士团队在Circulation Research上在线发表题为Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-fibrotic Protein Synthesis During Cardiac Fibrosis的研究【4】,首次揭示EPRS中的脯氨酰...
Protein synthesis rate was increased in any glial tumor even in low grades, but this increase was statistically more important in anaplastic tumor with aggressive growth. Methionine-tRNA synthetase (MetRS) catalyzes the formation of methionine-tRNA which is necessary for the initiation of protein ...
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1. ...