The identification of novel metabolites and the characterization of their biological functions are major challenges in biology. X-ray crystallography can reveal unanticipated ligands that persist through purification and crystallization. These adventitious protein-ligand complexes provide insights into new activit...
It covers the early days of tRNA research (from 1955-1980) and includes a brief description of the discovery of tRNA, its function in protein synthesis and methods for its purification and sequence analysis.Uttam L RajBhandaryDepartment of BiologyCaroline Koehrer...
In the chicken mitochondrial genome, the gene for tRNATyr overlaps by one nucleotide with the downstream tRNACys gene, which is located on the same strand... Shin-ichi,Yokobori,and,... - 《Journal of Molecular Biology》 被引量: 122发表: 1997年 Function of a tRNA gene promoter depends on...
Structure, biosynthesis, and function of queuosine in transfer RNA. Prog. Nucleic Acid Res. Mol. Biol. 28, 49–73 (1983). CAS PubMed Google Scholar Kasai, H., Kuchino, Y., Nihei, K. & Nishimura, S. Distribution of the modified nucleoside Q and its derivatives in animal and plant ...
A structural element in tRNAs containing a 3-nucleotide sequence complementary to the corresponding codon present in the mRNA. Argonaute proteins A family of proteins that directly bind and mediate the function of regulatory small RNAs. The eukaryotic family is divided into Argonaute proteins and PIWI...
tRNA biology has come of age, revealing an unprecedented level of understanding and many unexpected discoveries along the way. This review highlights new findings on the diverse pathways of tRNA maturation, and on the formation and function of a number of modifications. Topics of special focus incl...
1. Nucleic Acid Synthesis/Breakdown: RNA Synthesis/Function: Transfer RNA. Encyclopedia of Cell Biology. 2016 2.Porter J J, Heil C S, Lueck J D. Therapeutic promise of engineered nonsense suppressor tRNAs[J]. Wiley ...
Elongator function in tRNA wobble uridine modification is conserved between yeast and plants P>Based on studies in yeast and mammalian cells the Elongator complex has been implicated in functions as diverse as histone acetylation, polarized protein... Mehlgarten,Jablonowski,Wrackmeyer,... - 《Molecul...
influence on aminoacylation activity, but instead exhibit aminoacylation-independent, noncanonical functions unrelated to their catalytic function in protein synthesis[10,11]. Among these novel “moonlighting” activities are transcription and translation control, and regulation of pathophysiological processes...
tsRNAs can also participate in gene silencing by associating with the PIWI protein (PIWI) and act as piRNA (P-element-induced wimpy testis (PIWI)-interacting small RNAs) [41]. A key function of piRNAs is silencing transposon elements [42]. Ts-101 and ts-53 were reported to correlate with...