et al. A tRNA-derived small RNA regulates ribosomal protein S28 protein levels after translation initiation in humans and mice. Cell Rep. 29, 3816–3824.e4 (2019). The authors unravel a crucial function of tdRs in directing mRNA translation through changes in the secondary structure of ...
1. Nucleic Acid Synthesis/Breakdown: RNA Synthesis/Function: Transfer RNA. Encyclopedia of Cell Biology. 2016 2.Porter J J, Heil C S, Lueck J D. Therapeutic promise of engineered nonsense suppressor tRNAs[J]. Wiley ...
Recent years have seen a burst in the number of studies investigating tRNA biology. With the transition from a gene-centred to a genome-centred perspective, tRNAs and other RNA polymerase III transcripts surfaced as active regulators of normal cell physiology and disease. Novel strategies removing ...
themRNAandtransfertheirchargedaminoacidsintonewlysynthesizedpeptideduringproteintranslation.RecentstudieshaveshownthatthetRNAfragments(tRFs),whicharederivedfromspeci ccleavageoftRNA,arepresentinmanyspeciesundersomespeci cconditions.tRFsareaclassofnewregulatorsofgeneexpression,whichfunctioninmanyways.SometRFsfunctioninthe...
近年来取得了一系列重要研究成果,发表于Cell、 Cell Metabolism、Neuron、Trends in Neurosciences、Nature Structural & Molecular Biology等国际学术期刊。得到国家自然科学基金,科技部重点研发计划,中科院战略先导科技专项等项目支持。兼任中科院脑功能与脑疾病重点实验室副主任,衰老生物医学安徽省重点实验室副主任。
氨酰tRNA合成酶(aminoacyl-tRNA synthases,aaRSs)是一类古老的酶类家族,其经典功能是将氨基酸结合在与其对应的tRNA上,为蛋白质的合成提供物质基础。aaRS家族成员除了人们所熟知的经典功能(canonical function)外,它们在进化过程中增添了许多全新的“非经典功能(noncanonical function)”。这些功能在人体生理及病理变化中...
Structure, biosynthesis, and function of queuosine in transfer RNA. Prog. Nucleic Acid Res. Mol. Biol. 28, 49–73 (1983). CAS PubMed Google Scholar Kasai, H., Kuchino, Y., Nihei, K. & Nishimura, S. Distribution of the modified nucleoside Q and its derivatives in animal and plant ...
很多其他期刊比如 Nature Methods、Nature Chemical Biology、Molecular Cell、Trends in Biochemical Sciences 等也都专门发表评论。 加入南加州大学成立独立实验室之后,重新设计了上述流程中的几乎所有步骤,并迭代出第二版 PARIS2,将效率提升了 4000 多倍[2]。
关键词:tRNA;tRNA修饰;生物功能;人类疾病中图分类号:Q522+.1文献标志码:AFunctionofposttranscriptionalmodi cationsoftransferRNAsanditsrelationshipwithhumandiseasesZHOUMi1,2,LIURu-Juan1*,WANGEn-Duo1,2*(1StateKeyLaboratoryofMolecularBiology,InstituteofBiochemistryandCellBiology,ShanghaiInstitutesforBiological...
最新一期Nature Cell Biology(NCB, IF=21.3)共发表9篇研究论文,主题内容包括:着丝粒形成生物学、肠道微生物与癌症、肝脏带状区域分化调控、棕色脂肪组织发育、tRNA反密码子稳定性、细胞核内凝胶体结构、神经信号传导和行为调控、乳腺癌BRCA2突变的治疗靶点发现、醚脂代谢与细胞器生成。