Except for a failure to appreciate the ribosome binding function of tRNA which required a considerably larger molecule, this hypothesis proposed even before the existence of tRNA was known has proven to be surprisingly accurate in its description of the role of tRNA and aminoacyl-tRNA synthetases ...
This short description of protein biosynthesis reveals that tRNA interacts with many components of this process. To understand these interactions at the molecular level is the main objective of many studies of molecular biologists.This is a preview of subscription content, log in via an institution ...
To prevent ambiguity and to provide a clear description of individual tsRNA species, we will provide one of the most commonly used names for each molecule with position and length information as well as the initial names used in the original publications. Type I 5′ and 3′tsRNAs Type I ...
Transfer RNAs (tRNA) are quintessential in deciphering the genetic code; disseminating nucleic acid triplets into correct amino acid identity. While this decoding function is clear, an emerging theme is that tRNA abundance and functionality can powerfully impact protein production rate, folding, activity...
Plasmid Description Reference pDH103 GCN2-FL, FLAG-6× His–tagged GCN2 ORF under yeast GAL promoter in pEMBLyex4 (Cesareni and Murray 1987); 2μ This study pDH104 GCN2-FL-Y1119L R1120L (gcn2-FL-m2) in pDH103 backbone This study pDH109 GCN2-FL-K628R in pDH103 backbone This stu...
Disease description:A disorder due to mitochondrial respiratory chain complex defects. Clinical features are variable and include muscle weakness with hypotonia, central neurological disease with progressive external ophthalmoplegia, ptosis and ataxia, delayed psychomotor development, cardiomyopathy, abnormal li...
Description of plant tRNA-derived RNA fragments (tRFs) associated with argonaute and identification of their putative targets. Biol Direct. 2013;8:6. Article CAS Google Scholar Keam SP, Young PE, McCorkindale AL, Dang TH, Clancy JL, Humphreys DT, et al. The human Piwi protein Hiwi2 ...
Below is, first, a brief introduction to these complex modern proteins, then similarly a description of the presently known self-acylating RNAs, and finally an assessment of the question of possible resemblance. AMINOACYL-tRNA SYNTHETASE EVOLUTION Current aaRS are uniformly large proteins (Schimmel ...
for tRNA function, due to the position of the D-arm on the interior angle of the tRNA tertiary structure, between the anticodon and acceptor stem, and may have been preserved via purifying selection. Pairwise analyses of syntenic regions showed the divergence of specifictRNAPhegenes across the ...
resolution. We envision that Nano-tRNAseq will contribute to the study of the biological function of tRNA modifications in a wide variety of contexts, such as cancer, stress exposures or viral infection, and opens the possibility of exploiting these molecules as biomarkers of human health and ...