The flavonoid 7,8-dihydroxyflavone (7,8-DHF) is a tropomyosin-receptor-kinase B (TrkB) agonist that mimics the effects of brain-derived neurotrophic factor (BDNF). Upon binding to the TrkB receptor, signaling cascades are initiated that can promote neuronal survival and regeneration. The use ...
7,8-Dihydroxyflavone基础信息 产品名：7,8-Dihydroxyflavone;7,8-二羟基黄酮水合物;TrkB receptor激动剂;7,8-DHF;TrkB受体激动剂；TrkB receptor agonist；7,8-Dihydroxyflavone Hydrate CAS号：38183-03-8 结构式：c1ccc(cc1)c2cc(=O)c3ccc(c(c3o2)O)O 分子式：C15H10O4 分子量：254.24 (anhydrous ba...
BDNF activates its high-affinity receptor TrkB and promotes neuronal survival; restoring BDNF signaling is thus of particular therapeutic interest. In the present study, we evaluated the ability of a small-molecule TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) and its synthetic derivative 4-...
TrkB and TrkC agonist; brain penetrant 6037 2 Citations Show Size & Price HIOC Selective TrkB receptor agonist; neuroprotectant 5961 1 Citation Show Size & Price PF 06273340 Potent and selective pan-Trk inhibitor; peripherally restricted 6115 1 Citation 1 Review Show Size & Price page...
产品名:7,8-Dihydroxyflavone;7,8-二羟基黄酮水合物;TrkB receptor激动剂;7,8-DHF;TrkB受体激动剂;TrkB receptor agonist;7,8-Dihydroxyflavone Hydrate CAS号:38183-03-8 结构式:c1ccc(cc1)c2cc(=O)c3ccc(c(c3o2)O)O 分子式:C15H10O4 分子量:254.24 (anhydrous basis) ...
Purpose : Brain-derived neurotrophic factor (BDNF) and activation of its high affinity receptor tropomyosin kinase (Trk) B promote retinal ganglion cells (RGCs) survival following injury. In this study, we tested the effects of LM22A-4, a small molecule TrkB receptor-specific partial agonist, ...
Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling. PLoS One 9, e113397, doi:10.1371/journal.pone.0113397 (2014). Article PubMed PubMed Central ADS Google Scholar Szmydynger-Chodobska, J., ...
Here we show that the optimized δ-secretase inhibitor (#11a) or TrkB receptor agonist (CF3CN) robustly blocks δ-secretase activity separately, and their combination synergistically blunts δ-secretase, exhibiting promising therapeutic efficacy in 3xTg AD mouse model. The optimal δ-secretase ...
Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. Here we show that intravenous injection of Ab4B19, an agonistic antibody for the BDNF receptor TrkB, penetrates into ovarian follicles, activates TrkB signaling, and promotes ovary development. In...
Therefore, we aimed to scrutinize an active molecule that functions identical to BDNF in activating TrkB receptor and it's downstream targets for restoring neuronal survival in Huntington disease (HD). Data from in vitro Neuro-2a cell line showed that treatment with 7,8-dihydroxyflavone (7,8-...