negative breast cancer since the cancer cells have more genetic mutations, making them easier for the immune system to target. It can be used along with chemo in cases where the cancer has come back locally and surgery is not an option. Immunotherapy can also help before and after surgery ...
Metabolic profiling of triple- negative breast cancer cells reveals metabolic vulnerabilities. Cancer Metab 2017; 5: 6.Lanning NJ, Castle JP, Singh SJ, Leon AN, Tovar EA, Sanghera A, MacKeigan JP, Filipp FV, Graveel CR. 2017. Metabolic profiling of tri- ple-negative breast cancer cells ...
Hemin sensitizes triple-negative breast cancer to metformin by degrading BACH1, a University of Chicago-led team has found. (nito100/iStock/Getty Images Plus) 而近日由芝加哥大学科学家团队通过细胞系和小鼠肿瘤模型的研究表明,将2种治疗糖尿病和卟啉症的药物-二甲双胍&血红素 -进行组合,可以抑制三阴性乳...
Triple negative breast cancer characteristics Up to 20 percent of invasive breast cancers are classified as triple negative, which refers to the fact that the cells are estrogen receptor negative (ER-), progesterone receptor negative (ER-), and HER2 negative. Treatments that reduce the production ...
Inhibitor of apoptosis (IAP) proteins constitute a family of conserved molecules that regulate both apoptosis and receptor signaling. They are often deregulated in cancer cells and represent potential targets for therapy. In our work, we investigated the
OPEN Citation: Signal Transduction and Targeted Therapy (2017) 2, e17035; doi:10.1038/sigtrans.2017.35 www.nature.com/sigtrans ARTICLE ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism Adi Y Berman1, Subrata Manna1, Naomi S Schwartz1, Yardena E ...
There are a lot of unmet needs in patients with triple-negative breast cancer (TNBC). Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, has been used for decades to treat hypertriglyceridaemia and mixed dyslipidaemia. Rec
Triple negative breast cancer (TNBC) is one of the most aggressive types of breast cancer accounting for 12% of breast cancer cases. It is characterized by the lack of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2), which ...
Triple-negative breast cancer, Epidemic profile, Susceptibility genes, Genetic polymorphism, Biomarker Competing interests: The authors declare that they have no competing interests. References [1] Derakhshan F, Reis-Filho JS. Pathogenesis of Triple-Negative Breast Cancer[J]. Annu Rev Pathol, ...
Metformin induces unique biological and molecular responses in triple negative breast cancer cells. Cell Cycle 8, 2031–2040 (2009). CAS PubMed Google Scholar Jiralerspong, S. et al. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. ...