Blood samples were collected at the time of clinical evaluation and tested for biochemical parameters. Ankle brachial index (ABI) was measured at rest, in both lower limbs. Fontaine classification was used for severity assessment as follows: intermittent claudication (IC, Fontaine class II, n =...
Main body of the manuscript In a meta-organismal pathway that begins in the gut, gut microbiota convert dietary precursors such as choline, phosphatidylcholine, and L-carnitine into trimethylamine (TMA), which is absorbed and subsequently converted to trimethylamine N-oxide (TMAO) via the host enzy...
Trimethylamine N-oxideSurrogate analyte approachLC-MSThe application of dried blood spots in clinical research is becoming increasingly popular owing to its convenient collection, storage, and transportation compared to that of conventional biological samples. The potential of trimethylamine N-oxide and its...
Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite has been implicated in human health and disease. Its early detection in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many diseases. Hence, the development of reliable and rapid technol...
Background. Of all intestinal microbiome-derived metabolites, trimethylamine N-oxide (TMAO) has received increasing attention because of its potent role in colorectal cancer development. Accumulating...
Blood Purif. 2021;50(6):837-847. doi:10.1159/000512962 PubMedGoogle ScholarCrossref 34. Farhangi MA. Gut microbiota-dependent trimethylamine N-oxide and all-cause mortality: findings from an updated systematic review and meta-analysis. Nutrition. 2020;78:110856. doi:10.1016/...
Nuclear magnetic resonance studies of blood plasma and urine from subjects with chronic renal failure: identification of trimethylamine-N-oxide. 来自 NCBI 喜欢 0 阅读量: 39 作者:JD Bell,JA Lee,HA Lee,PJ Sadler,DR Wilkie,RH Woodham 摘要: We have used 1H-, 13C- and 14N-NMR spectroscopy ...
Figure 2.Changes in Trimethylamine N-oxide (TMAO) and its precursors in patients with PE, and source analysis of the microbiota. (a) Differences in TMAO and its precursor levels between the PE and NP groups by orthogonal partial least squares discriminant analysis (OPLS-DA). (b) Heat map ...
Chronic kidney disease (CKD) patients have an increased risk of cardiovascular diseases (CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine-N-oxide concentration (TMAO) in Chinese CKD patients and explore the underl
The host-microbiota co-metabolite trimethylamine N-oxide (TMAO) is linked to increased cardiovascular risk but how its circulating levels are regulated remains unclear. We applied “explainable” machine learning, univariate, multivariate and mediation a