综上所述，TMAO的检测在临床诊断和疾病预防中具有重要的意义。我们开发的基于LC-MS的TMAO检测方法具有高灵敏度、高特异性和操作简便等优点，适用于临床诊断和大规模筛查。未来，我们将继续深入研究TMAO的生理和病理作用，为疾病的预防和治疗提供更多的科学依据和技术支持。除了上述的检测方法外，TMAO的检测还可以采用其他...
Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease.| Thomas, MS. and Fernandez, ML. 2021. Curr Atheroscler Rep. 23: 12. PMID: 33594574 Trimethylamine N-oxide (TMAO) in human health.| Gatarek, P. and Kaluzna-Czaplinska, J. 2021. EXCLI J. 20: 301-319. PMID: 33746664 ...
The trimethylamine N-oxide (TMAO) is a gut microbiota derivative that has been suggested as a potential regulator of human health, especially (but not exclusively) for its association with cardiovascular diseases. It derives from the trimethylamine (TMA), which is produced by the gut microbiome ...
Trimethylamine N-oxide(三甲胺N-氧化物,TMAO)是一种氧化胺类有机化合物,通常在海洋生物的组织中发现,属于胺氧化物类,是一种膳食胆碱和其他含三甲胺营养素的肠道微生物依赖性代谢产物。TMAO可增加TGF-β受体I的表达,促进Smad2的磷酸化,上调α-SMA和胶原I的表达,激活TGF-βRI/Smad2通路,加速成纤维细胞向肌成纤维...
Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite has been implicated in human health and disease. Its early detection in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many diseases. Hence, the development of reliable and rapid technol...
Trimethylamine N-oxide |CAS 1184-78-7推荐 更新日期:2024-11-26 翌圣生物科技(上海)股份有限公司 联系人:翌圣生物 吴经理 手机:13916346489 QQ:3455256316 联系电话:021-34615975 在线询单 QQ交流 电话询单 产品编号 品牌 纯度 规格 库存 价格 53330ES 翌圣生物 ≥98% 100 mg 1000 145.00 元 53330ES 翌圣...
部分菌群可产生三甲胺裂解酶,将人体直接摄入或间接生成的胆碱转化为三甲胺,后者经门脉循环进入肝脏并被黄素单氧酶氧化生成氧化三甲胺(Trimethylamine N-oxide,TMAO)。TMAO具有疏水和亲水双重基团,可调节蛋白质活性和稳定性,增加泡沫细胞生成和抑制胆固醇逆向转运 [8]。基于高效液相--质谱的代谢组学的方法发现了卵磷脂...
产品名称 TMAO(Trimethylamine N-oxide) 产品规格 100 mg 用途范围 仅做科研,不用于临床 加工定制 否 商品货号 53330ES 商品规格 100 mg 生产厂家 翌圣生物科技(上海)股份有限公司 是否进口 否 规格编码 53330ES03 最小起订量 1.00 发货地 上海 售卖区域 全国 CAS号 1184-78-7 可售卖地 全国...
Trimethylamine N-oxide (TMAO) is an amphiphilic osmolyte that can counteract the denaturing effects of urea, pressure, and ice and stabilize the proteins.作为氧化剂用于 OsO4 催化的位阻烯烃的顺式羟基化反应;制备不稳定的、无水结晶化合物。 Reactant for: · C-H bond cleavage · Oxidation reactions...
(TMA), which is subsequently converted in the host liver and other tissues to trimethylamine N-oxide (TMAO), a multifunctional molecule that has profibrotic activity. This review summarizes the current state of knowledge of the role and mechanism of the meta-organismal microbe-TMA-TMAO axis in ...