real-time quantitative PCR analysis and ELISA detection showed that the synthesis and secretion of insulin were hindered. We used Trim-Way technology to specifically eliminate the excessive accumulation
Degradation of endogenous proteins and generation of a null-like phenotype in zebrafish using Trim-Away technologyTRIM21, Trim-away, Protein degradation, KnockdownTrim-Away is a recent technique to rapidly deplete a protein from any cell type. Guided by antibodies, TRIM21 selects proteins for ...
MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, P.R. China Qiong Guo, Xinyan Chen & Chao Xu Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney ...
Think about how you regularly sidle up to a bowl of ice cream while watching Leno, or stop at Wendy's for a late-night drive-thru snack. Modern technology has created an artificial daytime for us, and we're filling it up with meal four, meal five, and meal six. That extended eating...
Trim-Away is a recently developed technology that exploits off-the-shelf antibodies and the RING E3 ligase and cytosolic antibody receptor TRIM21 to carry out rapid protein depletion. How TRIM21 is catalytically activated upon target engagement, either during its normal immune function or when ...
Trim-Away is a recently developed technology that exploits off-the-shelf antibodies and the RING E3 ligase and cytosolic antibody receptor TRIM21 to carry out rapid protein depletion. How TRIM21 is catalytically activated upon target engagement, either during its normal immune function or when repurp...
grid.59053.3a0000000121679639MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and MedicineUniversity of Science and Technology of China Hefei P.R. ChinaChao Xugrid.59053.3a0000000121679639MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, ...