and hepatocellular carcinoma (HCC) represents approximately 90% of primary liver cancer [5,6]. In HCC, TRIM proteins have impacts on cell proliferation, apoptosis, cancer metastasis, metabolic reprogramming, stemness, carcinogenesis, immunogenicity, and resistance to cancer therapies. Furthermore, target...
The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function as E3 ligases to facilitate specif...
TRIM proteins in hepatocellular carcinoma. J Biomed Sci. 2022;29(1):1–69.10.1186/s12929-022-00854-7Search in Google Scholar PubMed PubMed Central [25] Huang N, Sun X, Li P, Liu X, Zhang X, Chen Q, et al. TRIM family contribute to tumorigenesis, cancer development, and drug ...
et al. TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma. Med Oncol 41, 79 (2024). https://doi.org/10.1007/s12032-024-02307-7 Download citation Received06 November 2023 Accepted17 January 2024 Published...
2023, Environmental Research Show abstract M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62 2023, Biology Direct TRIM proteins in hepatocellular carcinoma 2022, Journal of Biomedical ScienceView...
Hepatocellular carcinoma, TRIM52, PPM1A, UbiquitinationBackground Many tripartite motif (TRIM) family proteins have been reported to be of great importance in the initiation and progression in hepatocellular carcinoma (HCC). However, the biological role......
TRIM proteins, including TRIM24 and TRIM22, are also involved in p53 regulation. TRIM13 overexpression causes increased expression of p53, resulting in the induction of apoptosis. TRIM29 (also known as ATDC) regulates p53 through its interaction with TIP60. TRIM29 expression correlates with a poor...
Ubiquitination plays an important role in proliferating and invasive characteristic of glioblastoma (GBM), similar to many other cancers. Tripartite motif 25 (TRIM25) is a member of the TRIM family of proteins, which are involved in tumorigenesis through substrate ubiquitination. Methods Difference in...
Decreased expression of TRIM3 is TRIM3 在肿瘤中的研究进展 从雨,等 associated with poor prognosis in patients with primary hepatocellular carcinoma[ J]. Med Oncol, 2014, 31(8): 102. 27. Venuto S, Merla G. E3 ubiquitin ligase TRIM proteins, cell cycle and mitosis[ J]. Cells, 2019, 8...
Tumor cells often exhibit augmented capacity to maintain endoplasmic reticulum (ER) homeostasis under adverse conditions, yet the underlying mechanisms are not well defined. Here, through the evaluation of all human TRIM proteins, we find that TRIM25 is