TRIM proteins, including TRIM24 and TRIM22, are also involved in p53 regulation. TRIM13 overexpression causes increased expression of p53, resulting in the induction of apoptosis. TRIM29 (also known as ATDC) regulates p53 through its interaction with TIP60. TRIM29 expression correlates with a poor...
The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function
TRIM家族蛋白在肿瘤中的研究进展
Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of the blastocyst. These cells can proliferate indefinitely and differenti... R Eini,LCJ Dorssers,LHJ Looijenga - 《International Journal...
Identifying novel disease marker and clarifying the pathological mechanism will provide new insight into this disease and facilitate discovery of novel therapeutic strategies. In recent years, the role of tripartite motif (TRIM) proteins in the development of cancer has attracted much research interest,...
we focus on recent advances in the structures of TRIM proteins and their functions in the development of viral infection,cancer and neurodegenerative disease.%三结构域蛋白(TRIM)家族具有高度保守RBCC结构域,从N端到C端的顺序依次是RING锌指结构,一个或两个B-box结构域和一个卷曲螺旋结构域,RBCC结构域后...
proteins and innate immune regulation[J]. Curr Opin Immunol, 2011, 23(1): 46-56. [3]Nakamura Y, Oshima K, Naoi Y, et al. 14- 3- 3 sigma expression is associated with poor pathological complete response to neoadjuvant chemotherapy in human breast cancers[J]. Breast Cancer Res Treat, ...
[29] and there are more than 400 human KRAB-ZNF genes encoding transcripts for more than 700 different proteins [30]. This huge family of transcription factors is postulated to regulate diverse processes such as embryonic development, tissue-specific gene expression, and cancer progression [31]. ...
[4] Lu, Panrui et al. “Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders.” Cell, S0092-8674(24)01197-8. 30 Oct. 2024, doi:10.1016/j.cell.2024.10.015 *声明：本文仅是介绍医药疾病领域研究进展或简述研究概况或分享医药相关讯息，并非也不会...
Making sense of ubiquitin ligases that regulate p53 The functions of p53 most highly associated with the well-studied tumor suppressor are its abilities to induce cell cycle arrest and apoptosis in response ... AK Jain,MC Barton - 《Cancer Biology & Therapy》 被引量: 70发表: 2010年来源...