tRF-GluCTC-0005 (hereafter referred to as tRF-GluCTC) is a cleavage fragment of tRNA-GluCTC, 24 bases in length, formed by Dicer enzyme shearing from the 5’ end of tRNA, and contains the D-loop of the dihydrouridine region (Fig.3B). We isolated exosome from the peripheral blood samp...
We found that the tRF-GluCTC-0005 in exosomes binds to the 3' untranslated region of the mRNA of the WDRl in HSCs and increases mRNA stability. The N-terminals of WDR1 bind to the YAP protein directly, inhibit YAP phosphorylation, and promote the expression of YAP transcription factors. ...