In the last 10-15 years, secondary HLH has been increasingly recognized in adults, where it is frequently associated with lymphoid malignancy, infection, or autoimmune disease. This relatively recently recognized diagnosis and the treatment of adult HLH have been largely shaped by observations in ...
THU0557鈥匟aemophagosytic Limphohistiosytosis (HLH) in Adults. Diseases Triggers, Course, Treatment and Pronostic Factors. Differences Between Patients with Macrophage Activation Syndrome (MAS) and Other Causes of Secundary Heamophagosytic Limphohistiosytosis (SHLH). report Of Thirty-Two Cases...
Critically ill adults with COVID-19 were categorized according to whether they received or did not receive tocilizumab in the first 2 days of admission to the ICU. Data were collected retrospectively until June 12, 2020. A Cox regression model with inverse probability weighting was used to ...
In adults, sHLH is most commonly triggered by viral infections. sHLH is characterized by T-cell-mediated inflammation, fulminant cytokine storm, ferritin elevation and multi-organ failure. The HLH diagnostic criteria is based on the HLH Study Group of the Histiocyte Society 2004 description of ...
EBV-DNA copies in sorted T, B, and NK cells were also markedly decreased after sintilimab treatment. Conclusion Our data supported the efficacy of PD-1 targeted therapy in certain patients with CAEBV and EBV-HLH, and suggested that sintilimab could provide a cure for these diseases, without...
Emapalumab is indicated to treat both adults and children (newborn and older) who have refractory, recurrent, or progressive disease or intolerance with conventional HLH therapy, in combination with dexamethasone through intravenous infusion over 1 hour twice per week until hematopoietic stem ...
Greater detail regarding treatment strategies for MAS can be found in the HLH-2004 therapeutic guidelines (39). THERAPY The new advances in understanding the pathogenesis of s-JIA have revolutionized therapy for affected children. Until recently, the mainstay of therapy consisted of corticosteroids ...
Coronaviruses are a large family of enveloped, positive-strand RNA viruses that cause a substantial number of upper respiratory tract infections (URI’s) in children and adults [1] and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease pandemic...
OPDIVO® (nivolumab), in combination with YERVOY® (ipilimumab), is indicated for the treatment of adults and pediatric patients 12 years and older with microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (CRC) that has progressed following tr...
All patients had resolution of HLH-like symptoms with preserved CAR-T-cell expansion.33,34 Patients who receive blinatumomab infu sion, a CD19/CD3 BiTE antibody, are also at risk for CRS syndrome. In the phase 2 multicenter, single-group study that treated 189 patients with r/r ...