In the last 10-15 years, secondary HLH has been increasingly recognized in adults, where it is frequently associated with lymphoid malignancy, infection, or autoimmune disease. This relatively recently recognized diagnosis and the treatment of adult HLH have been largely shaped by observations in ...
One unit of platelets can theoretically increase the platelet count by 4 × 109 to 8 × 109/L in adults (70 kg body weight). For patients receiving antiplatelet therapy, bleeding-induced thrombocytopenia significantly increases mortality, blood loss, and the surgery rate [160, 161]....
Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening condition characterized by uncontrolled inflammation. The management of HLH is challenging, in part, due to the multiple etiologies of the disease, the variations in presentations, and the rapidity of the progression of the disease...
and since then, various types of primary and secondary HLH have been defined gradually. Mutations in genes associated with HLH have also been progressively discovered. CHS chédiak-higashi syndrome
Etoposide-based treatment is the standard of care for adult HLH in many centers, yet there remains a paucity of data regarding treatment outcomes. We conducted a retrospective study of 23 adults treated with etoposide-based therapy compared to 10 pediatric HLH cases at a single center. At diagno...
Identify CRS based on clinical presentation. Evaluate for and treat other causes of fever, hypoxia, and hypotension. CRS has been reported to be associated with findings of HLH/MAS, and the physiology of t...
First presentation of results from Phase 3 CheckMate -67T trial with subcutaneous formulation of Opdivo (nivolumab and hyaluronidase) to be shared in a late-breaking oral presentation Four-year data from CheckMate -9ER and unprecedented eigh...
Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disease of unknown etiology usually affecting young adults. AOSD was first described as a distinct clinical entity in the early 1970s by Eric Bywaters [1]. It is typically characterized by a triad of spiking fever, arthritis,...
Identify CRS based on clinical presentation. Evaluate for and treat other causes of fever, hypoxia, and hypotension. CRS has been reported to be associated with findings of HLH/MAS, and the physiology of the ...
potentially aiding in early intervention and improving the clinical outcome of HLH patients. To date, there is only one targeted therapy, emapalumab targeting interferon-γ, that has gained approval for primary HLH. This review aims to summarize the current treatment advances, emerging targeted thera...