For example, in patients with factor VIII deficiency, those with less than 1 % of the factor have severe disease, those with 2-5% of the factor have moderate disease, and those with 5-50% of the factor have mild disease. In factor XI deficiency, however, the phenotype does not in any...
Acquired hemophilia A (AHA) is a severe bleeding disorder with high mortality rates resulting from the development of autoantibodies to factor VIII (FVIII). Patients typically present with hemorrhages in the skin, subcutaneous tissues, and muscles, which are frequently severe. They can also develop ...
Export Citation for this Article Get Citation Alerts Request PermissionsAbstract References Cited By Get PDF (11K)Get PDF (11K) Keywords: factor VIII; inhibitor; treatment; cyclosporin; coagulopathy Abstract The treatment of Factor VIII inhibitors remains controversial and no standard therapy exists. We...
Therapeutic challenges in acquired factor VIII deficiency. Management of A is challenging and should be undertaken in close collaboration with a center with expertise in the field. Treatment involves controlling an... PW Collins - 《Hematology》 被引量: 51发表: 2012年 Rituximab for the treatment ...
Unresponsiveness to factor VIII inhibitor bypassing agents during haemostatic treatment for life-threatening massive bleeding in a patient with haemophilia... Summary. We report a case of haemophilia A with a high responding inhibitor of factor VIII (FVIII) who had a serious retroperitoneal haematoma ...
Two batches of heat-treated factor VIII concentrate were found to contain anti-HIV-positive plasma donations. The batches were dry-heat-treated at 68 degrees C for 2 and 24 h, respectively. No HIV seroconversions occurred in 13 susceptible haemophiliacs receiving a total of 540 bottles of thes...
Abstract 14633: A Case of Acute Coronary Syndrome With Incidental Acquired Factor VIII Deficiency With Inhibitor Present: How to Navigate Being Between a "... Introduction:Acute coronary syndrome (ACS) occurring in the presence of a bleeding diathesis can make clinical decision-making difficult. We...
摘要: An acquired antibody to factor VIII after exposure to sulfamethoxazole-trimethoprim caused massive lower tract hematuria which was unresponsive to multiple surgical procedures. Immunosuppression with cyclophosphamide and factor VIII replacement corrected the bleeding disorder....
Background Recombinant factor VIIa (rFVIIa) is used for haemophilic patients with inhibitors against coagulation factor VIII or IX, but there is also a... P.,I.,Johansson - 《Vox Sanguinis》 被引量: 43发表: 2008年 Treatment of haemophilia (factor VIII deficiency) with human anti-haemoph...
Autoantibodies against factor VIII (FVIII) develop in less than one individual per million per year and have a reported mortality between 6% and 22%.1, 2, 3 Most cases are idiopathic; up to 50% are associated with autoimmune diseases, malignancies, drugs, or the postpartum period.1, 4 Hum...