Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2semi-invariant TCR伪 that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites presented by MR1. MAIT cells are associated with immune control of bacterial and mycobacterial infections in murine models....
Human mucosal-associated invariant T (MAIT) cells have been described as an abundant population of αβ-T-cell antigen receptor (TCR) T cells that display antimicrobial Th1-like cytotoxic capacity upon detection of a range of microbial infections1,2,3. By definition, MAIT cells express a semi-...
Furthermore, MAIT cells with effector function have been found in the thymus, a finding that has been used to support their definition as innate-like13. While the role of MR1 and MAIT cells in human immunity is unclear, mouse studies have demonstrated their role in protection against ...