Human mucosal-associated invariant T (MAIT) cells have been described as an abundant population of αβ-T-cell antigen receptor (TCR) T cells that display antimicrobial Th1-like cytotoxic capacity upon detection of a range of microbial infections1,2,3. By definition, MAIT cells express a semi-...
Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2semi-invariant TCR伪 that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites presented by MR1. MAIT cells are associated with immune control of bacterial and mycobacterial infections in murine models....
Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2semi-invariant TCRα that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites presented by MR1. MAIT cells are associated with immune control of bacterial and mycobacterial infections in murine models....
摘要: MR1 presents vitamin B-related metabolites to mucosal associated invariant T (MAIT) cells, which are characterized, in part, by the TRAV1-2 展开 关键词: : Antigen presentation MAIT MHC-related molecule (MR1) T-cell receptor (TCR) atypical MAIT TCR crystal structure immunology major ...
In contrast to TRAV1-2 þ MAIT cells, this TRAV12-2-expressing clone displays a distinct pattern of microbial recognition by detecting infection with the riboflavin auxotroph Streptococcus pyogenes. As known MAIT antigens are derived from riboflavin metabolites, this suggests that TRAV12-2 þ ...