What is Trastuzumab and how does it work?Trastuzumab, also known as Herceptin (in mainland China and Hong Kong) or Herceptin (in Taiwan), is a monoclonal antibody that targets human epidermal growth factor receptor II (HER-2) and is primaril.. What is Trastuzumab and how does it work?Tra...
Approximately 20-30% of breast cancers exhibit HER-2 overexpression. HER-2 is a receptor on the cell membrane that has high specificity for human epidermal growth factor (EGF). When EGF binds to HER-2, it causes dimerization of HER-2, leading to autophosphorylation and subsequent intracellular ...
Side effects The main side effect of Trastuzumab is its impact on the heart, as HER-2 is also expressed on cardiac muscle cells. Therefore, Trastuzumab may affect cardiac function. It has been estimated that approximately 2-7% of patients using Trastuzumab may experience cardiac-related issues, ...
What kind of drug is Herceptin (trastuzumab), and how does it work? Herceptin is an intravenous drug that is part of a chemotherapy regimen that is used to prevent recurrence of breast cancer, and for the treatment breast cancer that has spread beyond the breast (metastasized). It belongs...
How does trastuzumab work (mechanism of action)? Trastuzumab stops the growth and development of cancer cells that express large amounts of a protein called HER2. Your cancer cells can be tested to see if trastuzumab is a possible medicine for you. How is trastuzumab supplied (dosage forms)?
How does trastuzumab work (mechanism of action)? Trastuzumab stops the growth and development of cancer cells that express large amounts of a protein called HER2. Your cancer cells can be tested to see if trastuzumab is a possible medicine for you. ...
A relevant biological question is how AXL is activated. Several studies reported that AXL could be activated both in a dependent or independent manner of its ligand GAS6. Exploration of the mechanism underlying trastuzumab resistance through AXL revealed that it happens in a ligand independent manner...
What are biologic drugs and how do they work? What biosimilars have been approved in the United States? What is Herceptin? Is Herceptin a chemo drug? How does it work? How long does Herceptin stay in your body?Lis... Taken for 1 to 6 months March 15, 2022 For Breast Cancer "Where...
How to Use Precautions Side Effects More Information Why is this medicine prescribed? Ado-trastuzumab emtansine injection is used to treat a certain type of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other medications. Ado-...
Trastuzumab emtansine, also known as T-DM1, is an antibody-drug conjugate used for the treatment of trastuzumab and pretreated HER2+ MBC. It has shown superior survival and a more favorable toxicity profile compared to other treatments in clinical trials. ...