Approximately 20-30% of breast cancers exhibit HER-2 overexpression. HER-2 is a receptor on the cell membrane that has high specificity for human epidermal growth factor (EGF). When EGF binds to HER-2, it causes dimerization of HER-2, leading to autophosphorylation and subsequent intracellular ...
Side effects The main side effect of Trastuzumab is its impact on the heart, as HER-2 is also expressed on cardiac muscle cells. Therefore, Trastuzumab may affect cardiac function. It has been estimated that approximately 2-7% of patients using Trastuzumab may experience cardiac-related issues, ...
What is Trastuzumab and how does it work?Trastuzumab, also known as Herceptin (in mainland China and Hong Kong) or Herceptin (in Taiwan), is a monoclonal antibody that targets human epidermal growth factor receptor II (HER-2) and is primaril.. What is Trastuzumab and how does it work?
What Is Ado-Trastuzumab Emtansine and How Does It Work?Ado-Trastuzumab Emtansine is a prescription medication used to treat the symptoms of breast cancer. Ado-Trastuzumab Emtansine is available under the following different brand names: Kadcyla
Trastuzumab is available as a powder in a vial containing 440 mg of the drug. It must be mixed with a liquid before intravenous injection. How should I keep it stored? Trastuzumab should be stored at 2 C to 8 C (36F to 46 F), and should not be frozen. ...
How is fam-trastuzumab deruxtecan given?Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using fam-trastuzumab deruxtecan.Fam-trastuzumab deruxtecan is given as an infusion into a vein. A healthcare provider will give you this ...
What are biologic drugs and how do they work? What biosimilars have been approved in the United States? What is Herceptin? Is Herceptin a chemo drug? How does it work? How long does Herceptin stay in your body? How do Herceptin (trastuzumab) and Perjeta (pertuzumab) work together?More...
How does Enhertu work (mechanism of action)? Enhertu is a type of medicine known as an antibody-drug conjugate (ADC). ADCs work as smart bombs to find cancer cells in the body that have (or express) a certain protein. Enhertu targets a protein called HER2. Once t...
Researchers requesting access to clinical study documentation only can do so via the following link: http://www.roche.com/research_and_development/who_we_are_how_we_work/clinical_trials/our_commitment_to_data_sharing/clinical_study_documents_request_form.htm. Documents are made available on ...
How long can I stay on Herceptin? What is TDM1 chemotherapy? What biosimilars have been approved in the United States? What is Herceptin? Is Herceptin a chemo drug? How does it work? How long does Herceptin stay in your body? How do Herceptin (trastuzumab) and Perjeta (pertuzumab) work ...