This paper synthetises preclinical and clinical data on pertuzumab and highlights the mechanisms underlying the synergistic activity of the combination pertuzumab-trastuzumab which are essentially due to their complementary mode of action.SandrineRichard...
This mode of action significantly influences the activity of gene promoters, thereby finely tuning gene expression levels [44]. Moreover, circRNAs may contribute to the modulation of the three-dimensional structure of chromatin by engaging in interactions with it, consequently affecting the epigenetic ...
et al. Mode of Action of Pertuzumab in Combination with Trastuzumab Plus Docetaxel Therapy in a HER2-positive Breast Cancer Xenograft Model. Oncol. Lett. 14, 4197–4205 (2017). Article CAS PubMed PubMed Central Google Scholar Jiang, H. et al. Claudin18.2-Specific Chimeric Antigen Receptor ...
Although T-DXd provides some clinical benefit in patients with HER2-overexpressing and HER2-low mBC, most of them will ultimately experience disease progression and die. Although the overall structure of T-DXd is well defined, several questions remain regarding its mechanisms of action and resistance...
The newn-mode coherent–entangled state and its application Trastuzumab and CNS metastases in women with HER-2 positive metastatic breast cancer. J Clin Oncol 2005 ASCO Annual Meeting Proceedings 2005; 23 (16 Supl... Hong-Qi,Li,Ting-Qi,... - 《Journal of Physics A Mathematical & Theoretical...
- 《Annals of Oncology Official Journal of the European Society for Medical Oncology》 被引量: 40发表: 2016年 HER2 Dimerization Inhibitor Pertuzumab - Mode of Action and Clinical Data in Breast Cancer to first-line combination therapy with docetaxel and trastuzumab significantly prolonged progression-...
New anti-HER2 agents with different mode of action and higher permeability to the central nervous system may have increased efficacy in the brain. The local management of brain metastases originating from breast cancer is dependent on patient performance status, the extent of brain involvement, and ...
Irrespective of the mode of harvesting, quantification by flow cytometry (Figure 1a) confirmed high levels of HER2 on BT474 and SK-BR-3 cells (commonly classified as HER2+++) and revealed significant HER2 surface expression on MCF-7 and MDA-MB-231 cells, whereas HCC1806 and HCC1937 cells ...
The breast cancer susceptibility FGFR2 provides an alternate mode of HER2 activation. Oncogene. https://doi.org/10.1038/onc.2014.440 (2015). Tan, L. et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc. Natl Acad. Sci. USA 111...
While Brewster Angle Microscopy showed discrete distinctive morphological patterns for the monolayers investigated, PM-IRRAS showed that Tmab caused an increased number of gauche conformers related to the CH2 stretching mode for the lipid acyl chains, suggesting molecular disorder. Furthermore, the ...