In this study, we investigated the impact of the endocannabinoid transport inhibitor AM404 on three rat models of anxiety: elevated plus maze, defensive withdrawal and separation-induced ultrasonic vocalizations. AM404 (1–5 mg kg−1, intraperitoneal (i.p.)) exerted dose-dependent ...
Regulation of auxin response by miR393-targeted transport inhibitor response protein 1 is involved in normal development in Arabidopsis. miR393, which is encoded by MIR393a and MIR393b in Arabidopsis, post-transcriptionally regulates mRNAs for the F-box auxin receptors TIR1 (Transport Inhibi... ...
D. Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Biochem. J. 300, 631–635 (1994). CAS PubMed PubMed Central Google Scholar Quon, M. J. et al. Insulin receptor substrate 1 mediates the stimulatory effect ...
Formation of carbamino compounds does not require the dissolved carbon dioxide to be hydrated and so is independent of CA. The reaction is very rapid and would be of particular importance in a subject who had received aCA inhibitor. Effect of Buffering Power of Proteins on Carbon Dioxide Carriag...
CRM 1 is responsible for intracellular transport mediated by the nuclear export signal. Discusses research which showed that the cytotoxin leptomycin B (LMB) is a potent and specific inhibitor of the nuclear export signal (NES)-dependent nucle... Fukuda,Makoto,Asano,... - 《Nature》 被引量: ...
First, these studies indicate an alternative cholesterol absorption pathway, which is not susceptible to the current cholesterol absorption inhibitor, ezetimibe. Secondly, we demonstrated that reducing dietary and biliary cholesterol absorption in the absence of a statin improved the post-prandial vascular ...
The response of aux1-7 was no different to the WT (P = 0.94, F = 0.01). In contrast, all mutant lines and the WT control examined showed equivalent root growth suppression when treated with various concentrations of the auxin transport inhibitor, TIBA (Figure 2B). Figure 2 ...
M. et al. Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import. Cell Microbiol. 21, e12953 (2019). Article PubMed CAS Google Scholar Fraser, J. E. et al. A nuclear transport inhibitor that modulates the unfolded protein response and ...
and gene transcription. Dysregulation of nuclear transport is linked to major human diseases such as cancer, neurodegenerative diseases, and viral infections. Selinexor (KPT-330), an inhibitor targeting the nuclear export factor XPO1 (also known as CRM1), was approved in 2019 to treat two types...
The response of aux1-7 was no different to the WT (P = 0.94, F = 0.01). In contrast, all mutant lines and the WT control examined showed equivalent root growth suppression when treated with various concentrations of the auxin transport inhibitor, TIBA (Figure 2B). Figure 2 ...