单胺能系统功能障碍可引起许多神经和精神疾病,包括帕金森病、运动过度障碍和抑郁症。利血平和丁苯那嗪抑制VMAT2分别可缓解高血压和亨廷顿病的症状。 2023年12月11日,中国科学院物理研究所姜道华及中国科学院生物物理研究所赵岩共同通讯在Nature在线发表题为“Transport and inhibition mechanisms of human VMAT2”的研究论...
Structure of the human dopamine transporter and mechanisms of inhibition Article Open access 07 August 2024 Data availability The three-dimensional cryo-EM density maps of the NETApo, NETNA, NETMrlA, NETZPD and NETBPP have been deposited in the Electron Microscopy Data Bank under the accession...
Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2 Article 01 November 2023 Drug inhibition and substrate transport mechanisms of human VMAT2 Article Open access 02 January 2025 Data availability The three-dimensional cryo-EM density maps of human VMAT25-HT, VMAT2RES, ...
Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Bode K A,Donner M G,Leier I,Keppler D.Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate[J].Biochem Pharmacol,... Bode KonradADonner MarkusGLeier InkaKeppler ...
Inhibition of Transport Processes in the Dog Colon 来自 Semantic Scholar 喜欢 0 阅读量: 11 作者: JWL Robinson 摘要: The dog colon, unlike that of other mammalian species, is capable of accumulating amino acids and monosaccharides by saturable, Na+-dependent transport mechanisms, and of ...
3.2. Inhibition of [3H]taurine uptake As shown in Table 1, [3H]taurine uptake was strongly inhibited (94% inhibition) by unlabeled taurine (5 mM). The uptake was also reduced by TauT and GAT substrates, including β-alanine, hypotaurine, and GABA by more than 76% at concentrations of 1...
The human transport protein SLC35B1 was recently postulated to mediate ATP/ADP exchange in the ER; however, the underlying molecular mechanisms mediating ATP uptake are not completely understood. Here, we extensively characterized the transport kinetics of human SLC35B1 expressed in yeast that was ...
Carbohydrate hydrolysis, transport and utilization were investigated in rats exposed to diminished motor activity for 90 days. Glycemic curves were examined using provocative tests with equivalent quantities (1.5 g/kg body weight) of poly-, oligo- and monosaccharides (starch, maltose, glucose). Simulta...
Transport and inhibition mechanisms of human VMAT2 Article 11 December 2023 Neurotransmitter recognition by human vesicular monoamine transporter 2 Article Open access 16 September 2024 Data availability Cryo-EM maps and coordinates have been deposited in the EMDB and wwPDB, respectively, with acce...
Transport and inhibition mechanisms of human VMAT2 Article 11 December 2023 Introduction Vesicle amine transport protein-1 (VAT-1) was originally isolated as a synaptic vesicle membrane protein, abundantly found in cholinergic synaptic vesicles, and suggested to be involved in vesicular transport1. VA...