2023年12月11日,中国科学院物理研究所姜道华及中国科学院生物物理研究所赵岩共同通讯在Nature在线发表题为“Transport and inhibition mechanisms of human VMAT2”的研究论文,该研究描述了人VMAT2与5-羟色胺和3种临床药物在3.5-2.8 Å络合的冷冻电镜结构,证明了VMAT2运输和抑制的结构基础。 利血平和酮舍林占据底物...
Drug inhibition and substrate transport mechanisms of human VMAT2 Article Open access 02 January 2025 Data availability The three-dimensional cryo-EM density maps of human VMAT25-HT, VMAT2RES, VMAT2TBZ and VMAT2KET have been deposited into the Electron Microscopy Data Bank under accession numbe...
Despite decades of research, its structure and the molecular mechanisms underpinning noradrenaline transport, coupling to ion gradients and non-competitive inhibition remain unknown. Here we present high-resolution complex structures of NET in two fundamental conformations: in the apo state, and bound to...
The aim of this study was to elucidate the molecular mechanisms of fusidate-induced hyperbilirubinemia by investigating its influence on hepatic transport systems in the canalicular membrane. Using canalicular membrane vesicles from rat liver, we determined the effect of fusidate on the adenosine 5′-...
Inhibition of Transport Processes in the Dog Colon 来自 Semantic Scholar 喜欢 0 阅读量: 11 作者: JWL Robinson 摘要: The dog colon, unlike that of other mammalian species, is capable of accumulating amino acids and monosaccharides by saturable, Na+-dependent transport mechanisms, and of ...
Furthermore, anandamide transport was inhibited by acute ethanol in a time- and dose-dependent manner. Interestingly, acute ethanol-induced inhibition of anandamide transport was abolished in neurons exposed to chronic ethanol, suggesting that the anandamide transport processes may play a role in the ...
This produced a sequence of voltage changes at the apical and basolateral membranes that had three operationally distinct phases. Phase 1 is generated by the combination of an apical membrane K+ diffusion potential and inhibition of the electrogenic Na(+)-K+ pump.TRUNCATED AT 400 WORDS) 展开 ...
Sepsis elicits severe alterations in cardiac function, impairing cardiac mitochondrial and pressure-generating capacity. Currently, there are no therapies ... Supinski,G.,S. - 《American Journal of Physiology Regulatory》 被引量: 178发表: 2009年 Caspase inhibition prevents cardiac dysfunction and heart...
Transport and inhibition mechanisms of human VMAT2 Article 11 December 2023 Neurotransmitter recognition by human vesicular monoamine transporter 2 Article Open access 16 September 2024 Data availability Cryo-EM maps and coordinates have been deposited in the EMDB and wwPDB, respectively, with acce...
inhibition, as its position would not hinder turn-over of the soluble domains, nor to copper delivery to the ATPase core, as it is located far away from the MB’ platform in all the recovered HMA4 structures. Instead, MBD−1probably serves a structural role, positioning the preceding MBDs...