2023年12月11日,中国科学院物理研究所姜道华及中国科学院生物物理研究所赵岩共同通讯在Nature在线发表题为“Transport and inhibition mechanisms of human VMAT2”的研究论文,该研究描述了人VMAT2与5-羟色胺和3种临床药物在3.5-2.8 Å络合的冷冻电镜结构,证明了VMAT2运输和抑制的结构基础。 利血平和酮舍林占据底物...
Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines Article Open access 02 January 2024 Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2 Article 01 November 2023 Drug inhibition and substrate transport mechanisms of human VMAT2 Art...
Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines Article Open access 02 January 2024 Transport and inhibition mechanisms of human VMAT2 Article 11 December 2023 Neurotransmitter recognition by human vesicular monoamine transporter 2 Article Open access 16 ...
VMAT2 Transport and Inhibition Mechanisms Revealed by Cryo-EMdopamineserotoninsubsequentNeurotransmitters are a class of signaling chemicals,including monoamines such as serotonin,dopamine,and histamine,which play a vital role in a variety of neurological activities,including mood,memory,growth and ...
Neurotransmitters are a class of signaling chemicals,including monoamines such as serotonin,dopamine,and histamine,which play a vital role in a variety of neurological activities,including mood,memory,growth and development,and drug addiction.The cytosolic neurotransmitters in presynaptic neurons must be t...
In summary, DATs of preadolescent males are more sensitive to prenatal MA exposure via changes in the reserve pool and those of preadolescent females to postnatal MA exposure via the same mechanism. The combination of prenatal and postnatal MA exposure increases the risk of dopaminergic deficits ...
However, the precise mechanism of TBZ interaction with VMAT2 remains unknown. Here we used a random mutagenesis approach and selected TBZ-resistant mutants. The mutations clustered around the lumenal opening of the transporter and mapped to either conserved proline or glycine, or to residues ...
Using a heterologous expression system, we now report that VMAT2 not only shows inhibition by histamine but also transports 3H-histamine. Interestingly, histamine differs from other monoamine transmitters and does not inhibit 3H-reserpine binding to VMAT2, indicating interaction at a distinct site. ...
Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines ArticleOpen access02 January 2024 Introduction Neurotransmitter:sodium symporters (NSS) are integral membrane transport proteins that regulate the spatiotemporal parameters of neurotransmission through the reuptake of ne...
Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines Article Open access 02 January 2024 Transport and inhibition mechanisms of human VMAT2 Article 11 December 2023 Introduction Vesicle amine transport protein-1 (VAT-1) was originally isolated as a synaptic ...