Substrate binding and inhibition mechanism of norepinephrine transporter Article 14 August 2024 Structure of the human dopamine transporter and mechanisms of inhibition Article Open access 07 August 2024 Data availability The three-dimensional cryo-EM density maps of the NETApo, NETNA, NETMrlA, ...
Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines Article Open access 02 January 2024 Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2 Article 01 November 2023 Drug inhibition and substrate transport mechanisms of human VMAT2 Art...
Our conclusion is that the inhibition of Ran-dependent nuclear transport observed upon ATP depletion in vivo results from a shortage of RanGTP rather than the inhibition of some ATP-dependent process. 展开 关键词: Ran nuclear transport ATP ribavirin ...
Characterization and inhibition by a wide range of xenobiotics of organic anion excretion by primary human hepatocytes Organic anion secretion by human hepatocytes was characterized using primary liver parenchymal cell cultures and the anionic fluorescent dye carboxy-2鈥 ,7... L Payen,A Courtois,JP Ca...
Rice (Oryza sativa L.) is one of the most important food crops, feeding half of the world’s population. However, rice production is affected by cadmium (Cd) toxicity. Due to an increase in Cd-contaminated soil and rice grains, and the serious harm to human health from Cd, research on...
However, arsenic transport by MRP1 has never been demonstrated directly, and the mechanism by which efflux occurs and the chemical nature of the transported species are still undefined. Exposure of cells expressing MRP1 to inorganic arsenic has been shown to result in the efflux of GSH and ...
These ground-breaking results demonstrate that highly selective inhibition of furin by the novel inhibitors BOS-981 and BOS-318 presents a promising mechanism for the reduction of aberrant ENaC-mediated Na + absorption. This strategy has the potential to rehydrate the airways, restore effective MCC ...
Sorry, something went wrong. Please try again and make sure cookies are enabled References 1 A Amaratunga, S.E Leeman, K.S Kosik, R.E Fine Inhibition of kinesin synthesis in vivo inhibits the rapid transport of representative proteins for three transport vesicle classes into the axon ...
System L activity was inhibited by both l -Hcy and dl –Hcy, comparable to model substrates including 2–aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH). System L constituted the major transport mechanism, with significant BCH inhibition (69%) of [ 35 S] l –Hcy uptake. System A ...
Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines Article Open access 02 January 2024 Transport and inhibition mechanisms of human VMAT2 Article 11 December 2023 Neurotransmitter recognition by human vesicular monoamine transporter 2 Article Open access 16 ...