Define transmembrane. transmembrane synonyms, transmembrane pronunciation, transmembrane translation, English dictionary definition of transmembrane. adj. Passing or occurring across a membrane. American Heritage® Dictionary of the English Language, F
Two critical residues (the glutamate next to the Walker B motif and the switch histidine in the H loop) that interact with the γ phosphate via water in the consensus sequence are replaced by serine in CFTR's NBD1. In addition, the consensus signature motif LSGGQ...
Reelin promotes L1-dependent neurite outgrowth and neuronal migrationin vitrovia its serine protease activity. Assessment of neuronal migration out of cerebellar explants from wild-type,reelerandL1-deficient (L1−/y) mice (a,b) and assessment of neurite lengths in dissociated wild-type,reelerandL1...
Figure 1. AC6 is the most dominant AC isoform in the gut. A, RNA-Seq data demonstrate relative abundance of ACs in the mouse (n = 3) and human intestinal epithelial cells (n = 6). Error bars, S.D. B, breeding scheme followed to generate Adcy6Δ/Δ (Adcy6flox/flox shhCre+) ...
The inhibitory effect of BI-1 on ER stress appears to be mediated via a direct interaction with inositol-requiring enzyme 1α (IRE1α), an ER resident serine/threonine protein kinase and endoribonuclease, which induces the expression of genes implicated in the unfolded protein response [4]. ...
Thus, the consensus site for phosphorylation by serine/threonine specific kinases is maintained. Four other residues in this region are identical and six residues are similar to the respective residues in the P2X7(a) variant. Despite this apparent similarity, the P2X7(k) differs from all other ...
The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. J. Biol. Chem. 1999, 274, 27857–27866. [CrossRef] [PubMed] 3. Stahn, C.; Buttgereit, F. Genomic and nongenomic effects of glucocorticoids. Nat. Clin. Pract. Rheumatol....