Type II transmembrane serine proteases 4 (TMPRSS4) is a newly discovered transmembrane protein, which may be related to the invasion, metastasis of the tumor and the poor prognosis. This study aims to investigate the role of TMPRSS4 in endometrial cancer and the detailed molecular mechanism. ...
Type II transmembrane serine proteases (TTSPs) are related to tumor growth, invasion, and metastasis in cancer. Genetic variants in these genes may alter their function, leading to cancer onset and progression, and affect patient outcome. Here, 464 breast cancer cases and 370 controls were genoty...
Defective proteolysis has been implicated in hearing loss through the discovery of mutations causing autosomal recessive nonsyndromic deafness in a type II transmembrane serine protease gene, TMPRSS3. To investigate their physiological function and the contribution of this family of proteases to the ...
TMPRSS2 (transmembrane serine proteinase 2) is a multidomain type II transmembrane serine protease that cleaves the surface glycoprotein HA (haemagglutinin) of influenza viruses with a monobasic cleavage site, which is a prerequisite for virus fusion and propagation. Furthermore, it activates the fusi...
Membrane-anchored extracellular serine proteases, such as the type II transmembrane proteases Matriptase (also named Supressor of tumorgenicity 14/St14) and Hepsin, and the GPI-anchored protease Prostasin/Prss8, play crucial roles during numerous developmental processes and the manifestation of various ...
Cell surface proteases membrane proteins Expression of Meprins in Health and Disease Type II Transmembrane Serine Proteases DPPIV, Seprase and Related Serine Peptidases in Multiple... S Zucker 被引量: 9发表: 2003年 加载更多来源期刊 ONCOLOGY -BASEL- 研究点推荐 Seprase Diffuse-Type Gastric Cancer...
DPP4 is a type II integral transmembrane glycoprotein expressed on many cell types, but appears also in soluble form in body fluids including cerebrospinal fluid1. As a serine protease, DPP4 cleaves dipeptides from oligopeptides and proteins containing proline/alanine in the penultimate position. DPP4...
Our data are consistent with a specific modulation of Dectin-1 signalling by SPPL2 proteases as treatment with the Dectin-1 blocking antibody in most cases abolished the effect of protease-deficiency. However, as the majority of CLRs are type II transmembrane proteins, it is tempting to speculate...
Canonical pathway occurs by binding to the cell surface receptor angiotensin-converting enzyme 2 (ACE2) and then, the transmembrane protease serine 2 (TMPRSS2) cleaves the viral spike protein, allowing fusion of cellular and viral membranes. Non-canonical pathways would involve other proteases: ...
7). For that, we first identified RBCs based on the expression of CD235a (glycophorin A), a transmembrane glycoprotein expressed by erythrocytes, and then determine the frequency of antigen H+ cells (see the gating strategy in Supplementary Fig. 16) with 2 different anti-H blood group ...