Transcription and translation rates are also known to be correlated12, raising the question of how elongation speeds in both processes are communicated between the two macromolecular machineries. One possibility is that communication happens by the alarmone (p)ppGpp, which affects both transcription and...
Recent work has shown elongation rates are probably altered during mitosis and certain types of synaptic transmission. Other work has shown premature termination of mRNAs lacking stop codons appears to repress their translation. Together, these studies highlight the importance of translational control in...
coli (2,101 motifs, 0.49 motif/protein),13 shown to cause ribosome stalling,9 underscores the need for an EF-P with maximal functionality to maintain proteome homeostasis, especially at high growth rates.28 Many representatives of Actinobacteria have an even higher number of XPPX motifs within ...
Detection of nonneutral substitution rates on mammalian phylogenies. Genome Res. 20, 110–121 (2010). CAS PubMed PubMed Central Google Scholar Liu, Y. et al. Multi-omic measurements of heterogeneity in HeLa cells across laboratories. Nat. Biotechnol. 37, 314–322 (2019). CAS PubMed ...
Prices may be subject to local taxes which are calculated during checkout Additional access options: Log in Learn about institutional subscriptions Read our FAQs Contact customer support Data availability RNA-seq, MeRIP–seq, RIP-seq and eCLIP–seq data that support the findings of this study have...
it was shown that exposure to chemical mutagens such as the chemical benzene could produce chromosome breakage and increase DNA mutation rates.35,36In the 1980s, the process of carcinogenesis was described, with necessary conditions of DNA mutations generated due to environmental mutagen insult and ...
To explore this possibility, we initially investigated the impact of the eIF4G microexons on global protein synthesis rates. Puromycin incorporation into nascent polypeptides reveals a modest but significant increase in the translation rates of the microexon DKO neurons (Figure 6C; p < 0.05; two-...