Elongation factor TuEukaryotic elongation factor 1αEukaryotic elongation factor 2Fusidic acidKirromycinTranslational elongation factors are proteins that play two important roles during the elongation cycle of protein biosynthesis on the ribosome. First, elongation factors are involved in bringing aminoacyl-...
Translation elongation factors perform critical functions in protein synthesis in all domains of life, including the delivery of aminoacyl-tRNAs into the ribosome, and the translocation of peptidyl-tRNA from the ribosomal A-site to the ribosomal P-site. Elongation factor Tu (EF-Tu, EF1-alpha) is...
Translation elongation factor Tu cleaved by a phage-exclusion system. Bacteriophage T4 multiplies poorly in Escherichia coli strains carrying the defective prophage, e14; the e14 prophage contains the lit gene for late inhibi... Yuen-Tsu Nicco Yu and Larry Snyder - 《Proceedings of the National ...
Our results suggest that 2′-O-methylation sterically perturbs interactions of ribosomal-monitoring bases (G530, A1492 and A1493) with cognate codon–anticodon helices, thereby inhibiting downstream GTP hydrolysis by elongation factor Tu (EF-Tu) and A-site tRNA accommodation, leading to excessive ...
多肽链延伸因子 polypeptide chain elonga-tion factor 蛋白质生物合成中参与多肽链延伸过程的蛋白质因子。从大肠杆菌等原核细胞可纯化获得三种延伸因子(elongation factor),即eftu,efts和efg,分子量大约分别为4.7万,3.6万和8.3万。eftu与gtp结合成eftu-gtp,然后再与氨酰trna结合,形成三复合体(ternary complex)氨酰...
This protein participates in the elongation step of mitochondrial translation by binding and stabilizing the translation elongation factor Tu (EF-Tu). Bioinformatics analysis predicted a destabilization of the EF-Ts variants complex with EF-Tu, in agreement with the dramatic steady-state level reduction...
23、因子G,elongation factor G)原核延原核延长因子长因子生物功能生物功能对应真核对应真核延长因子延长因子EF-Tu促进氨基酰促进氨基酰-tRNA进入进入A位,结合位,结合分解分解GTPeEF-1-EF-Ts调节亚基调节亚基eEF-1-EF-G有转位酶活性,促进有转位酶活性,促进mRNA-肽酰肽酰-tRNA由由A位前移到位前移到P位,促进卸载位...
Elongation factor 1 alpha(EF1α)is a major translational factor.EF1α·GTP catalyzes the binding of aminoacyl-tRNA to the A-site of the ribosome.It is not only a protein necessary for translation but also one of the most important multifunctional proteins.EF1α has been shown to be concerned...
eukaryotic translation elongation factor 1 alpha 1, like 1 (eef1a1l1) Proteins eukaryotic translation initiation factor 1A (Eif1a) Proteins C76390 Proteins chunp6927 Proteins eef1a Proteins ef1a Proteins Ef1a Proteins EFL1-alpha Proteins
延伸过程所需蛋白因子称为延长因子(elongation factor, EF): 原核生物:EF-T (EF-Tu, EF-Ts);EF-G 真核生物:EF-1、EF-2 (一)进位又称注册(registration:指根据mRNA下一组遗传密码指导,使相应氨基酰-tRNA进入核蛋白体A位。核蛋白体对氨基酰-tRNA进位具有校正作用 (二)成肽是由转肽酶(transpeptidase)催化...