Characterisation of translation elongation factor e EF1B subunit expression in mammalian cells and tissues and co-localisation with e EF1A2. Cao Y,Portela M,Janikiewicz J et al. PLo S One . 2014Cao Y,Portela M,Janikiewicz J,et al.Characterisation of translation elongation factor e EF1B ...
Contrary to more classical GSTs having a role in toxic compound detoxification, eEF1Bγ is suggested to act as a scaffold protein, anchoring the elongation factor complex EF1B to the endoplasmic reticulum. In this study, we show that eEF1Bγ from the basidiomycete Phanerochaete chrysosporium is...
The eukaryotic translation elongation factor eEF-1B1 (EF1B) is a guanine nucleotide exchange factor that plays an important role in translation elongation... H Zakir,A Lisa,MG Brian,... - 《Plos One》 被引量: 247发表: 2012年 Identification of two genes coding for the translation elongation...
Elongation factor 1 alpha(EF1α)is a major translational factor.EF1α·GTP catalyzes the binding of aminoacyl-tRNA to the A-site of the ribosome.It is not only a protein necessary for translation but also one of the most important multifunctional proteins.EF1α has been shown to be concerned...
We also implemented CNOT3-EEF1E-PLA and CNOT3-EEF1D-PLA and validated the interaction between CNOT3 and translation elongation factors (Fig. 6H–K). To further assess the requirement of the NOT box domain for the association of CNOT3 with the translation machinery, we used the CNOT3-FL ...
L. Mechanism of protein synthesis inhibition by didemnin B in vitro. Biochemistry 34, 9177–9184 (1995). 35. Losada, A. et al. Role of the eukaryotic elongation factor eEF1A in the mechanism of action of Aplidin. In 105th Annual Meeting of the American Association for Cancer Research, ...
Translation elongation factors perform critical functions in protein synthesis in all domains of life, including the delivery of aminoacyl-tRNAs into the ribosome, and the translocation of peptidyl-tRNA from the ribosomal A-site to the ribosomal P-site. Elongation factor Tu (EF-Tu, EF1-alpha) is...
Deregulated expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation. of PU.1 in erythroid differentiation we transfected MEL cells with a PU.1 cDNA controlled by the eucaryotic translation elongation factor EF1 alpha promoter... G Rao,N Rekhtman,G Chen...
二、二、 Elongation Factor (EF, 延伸因子延伸因子)(一)(一)Prokaryotic Elongation Factors1 EF-TU With the presence of GTP, EF-TU •GTP can interact with aminoacly-tRNA to form a stable EF-TU •GTP• AA- tRNA complex, and bring the AA-tRNA into the A site according to the ...
Ribosomal translocation moves the mRNA through the ribosome by 3 bases.;;The completion of translocation requires the action of a second elongation factor called EF-G. EF-G can only bind to the ribosome when associated with GTP. After the peptidyl transferase reaction, the shift in the location...