dogA total of 16 dogs were brought with a history ofpainful urination and voiding red coloured urineUrinary sediments were subjected to cytologicalexamination. It revealed clusters of variablesized, round to polygonal neoplastic cells withbinucleate to multinucleate. indistinct nucleoliand mitotic figures...
Cells were represented by two types of epithelial elements. A first type consisted of single or small groups of epithelial elements in dysplastic squamous features. The second type was represented by more or less large epithelial aggregates with basophilic, vacuolated cytoplasm and rounded margins. ...
Cells in long term culture may accumulate gene mutations. There are numerous studies that show the correlation of the expression profiles of tumor markers in K9TCC with human TCC. The uroplakins are species-conserved integral membrane proteins that are present on the apical membrane of the ...
Physical urinalysis revealed presence of blood clots and tissue in urine, pH value of 6.5 as well as a specific gravity of 1.025 while presence of intact RBCs and clumps of transitional epithelial cells were observed on microscopic urinalysis. The case was confirmed to be of TCC of urinary ...
Cystocentesis may result in seeding tumour cells, so urine is generally collected by catheterization (may be difficult with the presence of an obstructive mass) or free catch when TCC is suspected. Urinalysis may reveal neoplastic cells in the sediment of approximately 30% of dogs with TCC. ...
In addition, neoplastic cells also showed abundant eosinophilic cytoplasm with large nucleus. Melamed-Wolinska bodies characteristic of these type of neoplasm representing large vacuoles containing stippled eosinophilic materials were observed.Thus, a case of Transitional Cell Carcinoma (TCC) was diagnosed ...
Regular expression of COX-1 has been described in normal urinary bladder epithelium, but intense COX-2 expression was found in canine TCC [12]. There are different examination methods to evaluate COX-2 expression: Khan et al. estimated the percentage of COX-2 positive neoplastic cells and ...
Cells in long term culture may accumulate gene mutations. There are numerous studies that show the correlation of the expression profiles of tumor markers in K9TCC with human TCC. The uroplakins are species-conserved integral membrane proteins that are present on the apical membrane of the ...