Google Share on Facebook transfer factor Thesaurus Medical Legal Financial Acronyms Encyclopedia Wikipedia n. Any of various small proteins that are obtained from donors with cell-mediated immunity to certain antigens and can confer this immunity when given to nonimmune recipients. ...
Cancer cells in the tumour microenvironment use various mechanisms to evade the immune system, particularly T cell attack1. For example, metabolic reprogramming in the tumour microenvironment and mitochondrial dysfunction in tumour-infiltrating lympho
Investigation of the uniqueness of chromatin accessibility in multiomics integration at the ATAC level showed that ATAC contributed more than did ADT and RNA to the integration of a subcluster of CD4+naive T cells (Methodsand Fig.2h–j). We took the ratio of peak number of a cell to that...
Having observed mitochondria transfer from the TME to mouse and human GBM models, we proceeded to interrogate the identity of the host mitochondria donor cells. GBM tumors in mouse models and humans are known to have substantial infiltration by both brain-resident glia and peripheral immune cells t...
Thus, due to their unique regulation in the nervous system, dysregulation of core translation factors, as well as their protein partners, can disrupt neurodevelopment. The extent to which these pathologies are due to impaired translation and cell fate specification remains to be determined. ATP-...
Moreover, factors that govern mitochondrial transfer include mitochondrial autophagy [94, 95], KIF5B, glucose [96], ATP [65], TNF-α [12], and the microenvironment of BMSCs. Functionally normal mitochondria are able to be transmitted from MSCs into receptor cells, while injured mitochondria in...
Besides, each phase is divided into two sub-phases, which is controlled by function evaluations and various factors of heat transfer phases. Thus, the value of design variables can move small or large as all three modes of heat transfer have equal probability to transfer heat. The large and ...
The EVs (exosomes and ectosomes) affect immune cells by induction of anti-inflammatory macrophages, regulatory dendritic cells, regulatory T and B cells, and inactivation of T cells; halt cytokine storm and pro-angiogenic action; and secrete a variety of bioactive and immunomodulatory factors. These...
Factors to consider for adoptive therapy by NK cells against SARS-COV-2 infections. NK cells have a pivotal antiviral role, directly targeting virus-infected cells with cytotoxic granules (perforin and granzymes) and regulating immune responses by secreting cytokines such as IFN-γ. The success of...
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for these fascinating molecules. Advances in tRNA detection methods have revealed t