Through a genome-wide analysis of DNA methylation across 19 cell types with T-47D as reference, we identified 106,252 cell type-specific differentially-methylated CpGs categorized into 7,537 differentially (46.6% hyper- and 53.4% hypo-) methylated regions. We found 44% promoter regions and 75%...
Learn about mRNA transcription. Discover where and how DNA is transcribed into RNA in prokaryotes and eukaryotes, and examine the final product of...
Comparative analysis on the expression of L1 loci using various RNA-seq preparations. Mob. DNA 11, 2 (2020). Article CAS PubMed PubMed Central Google Scholar Jachowicz, J. W. et al. LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo. ...
The regulation of gene expression is one of the most important mechanisms underlying proper cell function. Dysregulation of gene expression results in diseases such as developmental disorders and cancer. Gene expression is regulated by transcription factors (TFs) that bind to DNA by recognizing specific...
The +1 G of the RNA polymerase promoter sequence in the DNA template is the first base incorporated into the transcription product. To make sense RNA, the 5' end of the coding strand must be adjacent to or just downstream of, the +1 G of the prom...
documents published in that journal. The chart shows the evolution of the average number of times documents published in a journal in the past two, three and four years have been cited in the current year. The two years line is equivalent to journal impact factor ™ (Thomson Reuters) ...
In light of these findings, we aim to comprehensively profile the global landscape of TF motif enrichment and their relationship to hepatobiliary lineage commitment factors in PLC. TFs are important regulators of lineage determination.7 Mechanistically, TFs bind to specific DNA sequences, or motifs, ...
Transcription factors (TFs) interpret the genome directly, and are responsible for decoding DNA sequences [1]. It is reported that transcriptional factors are key components of cells that control gene expression, determining how the cells function [2]. Transcription factors acting as conductor orchest...
Pseudomonas syringae is a Gram-negative and model pathogenic bacterium that causes plant diseases worldwide. Here, we set out to identify binding motifs for all 301 annotated transcription factors (TFs) of P. syringae using HT-SELEX. We successfully iden
Mutation of periodic aromatic residues reduced transcriptional activity, whereas increasing the aromatic dispersion of multiple human TFs enhanced transcriptional activity and reprogramming efficiency, promoted liquid–liquid phase separation in vitro and more promiscuous DNA binding in cells. Together with ...