它不仅揭示了此前未知的DNA互作蛋白质组(DNA-interacting proteome)的全面图景,发现了大量具有高度“无序区域”(Intrinsically Disordered Regions, IDRs)的蛋白质在DNA结合中的关键作用;还让我们得以追踪雌激素受体(ESR1)等转录因子(transc...
它不仅揭示了此前未知的DNA互作蛋白质组(DNA-interacting proteome)的全面图景,发现了大量具有高度“无序区域”(Intrinsically Disordered Regions, IDRs)的蛋白质在DNA结合中的关键作用;还让我们得以追踪雌激素受体(ESR1)等转录因子(transcription factors)如何响应外部信号而迅速“奔赴”DNA,以及DNA修复(DNA repair)蛋白...
●基本概念●转录起始：RNA聚合酶、启动子●转录的基本过程●转录后加工●原核生物与真核生物mRNA的特征比较●RNA合成与DNA合成异同点 思考题？一、基本概念与基本特征 转录(transcription)：基因转录是在细胞核内进行的。它是指以DNA的一条链为模板，按照碱基互补配对原则，合成RNA的过程。转录 DNA RNA 参与转录的...
Sign in to download full-size image Figure 3.16. RNA processing. The precursor mRNA, produced by transcription, undergoes RNA processing while still within the nucleus. A 7-methylguanosine cap is added to the 5′ end of the transcript, while 50 to 250 adenine nucleotides are added to the 3...
transcription转录(transcription) 以DNA为模板,在RNA聚合酶作用下合成RNA的过程 promoter启动子(promoter): 与基因转录启动有关的特定保守序列;启动子本身不被转录 transcription factor反式作用因子 又称调节蛋白(DNA结合蛋白DBP,或转录因子TF) 基本转录因子:是RNA聚合酶结合启动子所必需的一组蛋白因子,决定三种RNA(mRNA...
S2E模型仅以DNA序列作为输入,能预测多种转录活性测量值,包括直接预测基因表达水平测量(RNA-seq)或替代指标(如表观基因组图谱数据,如ChIP-seq、ATAC-seq)。模型通过调整参数来最小化预测与实验测量值之间的差异,这需要大量输入数据和数百万个参数拟合。
This transcript serves both as a template for reverse transcription to give the negative DNA strand and for expression of at least some of the ORFs. Species in genus Caulimovirus produce a specific mRNA (19S RNA) for ORF6; no sgRNAs have been reported for genera Petuvirus, Soymovirus, ...
4b). Strikingly, Usp7 RNA interference (RNAi) led to more than approximately sixfold induction of 2CLCs (Fig. 3c) and a concomitant increase in the transcription of the MERVL retrotransposon (Extended Data Fig. 4c), a marker of 2CLCs and 2-cell-stage embryos. The 2CLCs induced upon Usp...
DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II DNA damage inhibits elongating RNA polymerase II, but also initiates genome-wide transcriptional responses. Here the authors reveal that particularly promoter-bound Pol II is degraded upon DNA damage ...
百度试题 题目逆转录(reverse transcription):以RNA为模板合成DNA的过程。相关知识点: 试题来源: 解析 正确 反馈 收藏