Indeed, H3.3 is required for de novo global transcription and embryonic development62. Molecular studies to determine the position and the number of origins used are currently impossible in embryos or 2CLCs, primarily because techniques to identify origins require amounts in the millions of cells. ...
I wrote about this new AI full text transcription tool, here. You’ll see two features which may help you. Using the “Find Help with AI Search” feature, type in what you’re searching for. I find the Full Text Search” to be much more helpful. Click on “Go to Experiment.” ...
16e–g). As observed in cell lines, intercellular differences in MYCN transcription positively correlated with relative ecDNA content (Supplementary Fig. 16h,i). Thus, scEC&T-seq can be successfully applied to human tumors. Fig. 6: scEC&T-seq detects circular DNAs in primary neuroblastomas at...
First, the longer loop regions, where the unpaired duplex DNA is wound on nucleosomes, function genetically by transcription into RNA. Second, the lateral extensions, without nucleosomal loops, join adjacent chromatids. Third, shorter loops of duplex DNA, that retain pairing in the 7-nm fibers,...
Igm synthesis involves transcription and rearrangement of the H genes (to obtain the VDJ block) and of the constant region of the μ and δ genes, including two exons encoding the transmembrane segment. During RNA splicing, the selection of the exons corresponding to the constant domains of the...
Tissue-specific gene expression is generally regulated by combinatorial interactions among transcription factors (TFs) which bind to the DNA. Despite this known fact, previous discoveries of the mechanism that controls gene expression usually consider on
only overlaps >20 are labeled. A small number of overlaps between clsy2 and clsy3 are not shown due to spatial constraints, but an unscaled Venn diagram showing all overlaps is present in Supplementary Fig. 1f. a, 基于补充表4中提供的24nt-siRNA簇减少的缩放维恩图显示了clsy single mutants...
[15,16,17]. A critical concern while measuring the abundance of L1 mRNA transcripts is parsing full-length L1 mRNA transcripts produced from the L1 promoter and truncated or full-length L1 sequences incorporated into cellular transcripts via passive transcription from non-L1 promoters [13,16,18,...
strand is shown in teal.cThe four-state model describing the kinetic operation of a transcription antenna. The description of the model (states and rate constants) and its physical properties are given in Methods.dDiagram representing the β3 tubulin transcription antenna four-state kinetic model ...
Transcription factor (TF)-binding motif analysis revealed enrichment of IRF3 and EP300, two TFs that have been implicated in SZ risk49,50,51 (Supplementary Fig. 20b). We were able to validate these findings using chromatin immunoprecipitation (ChIP)-seq data for EP300 (Fig. 4d and ...