Innate lymphoid cells (ILCs) play important functions in immunity and tissue homeostasis, but their development is poorly understood. Through the use of single-cell approaches, we examined the transcriptional and functional heterogeneity of ILC progenito
Nature Cell Biology volume 26, pages 1309–1321 (2024)Cite this article 20k Accesses 88 Altmetric Metrics details Abstract Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is unclear. Here we provide ...
Figure 1. The Foxp3gfp Allele (A) Maps of the targeting construct and targeted Foxp3gfp allele. Asterisks denote the location of external probes used for a Southern blot screen of ES cell clone DNA digested with the indicated restriction endonucleases. Black triangles denote oligonucleotide primer...
In subject area: Neuroscience A transcription initiation site is the location on a DNA molecule where the process of transcription begins. It determines the structure of the 5'-UTR and can contain features that inhibit translation. AI generated definition based on: Mechanisms of Development, 2001 ...
The cell cycle comprises a series of temporally ordered events that occur sequentially, including DNA replication, centrosome duplication, mitosis, and cytokinesis. What are the regulatory mechanisms that ensure proper timing and coordination of events d
(Fig.1A). In terms of the number of hDEGs, the cell type that was most affected was male ODC, which had 1,114 hDEGs (Additional file2: Table S1). Interestingly, fetal hypoxia affected the expression of more genes than were altered by sex (Additional file2: Table S2). A small ...
Poly(dA:dT) tracts are often found in the nucleosome-depleted regions that demarcate eukaryotic core promoters [2, 3, 5] and their length and location relative to the transcription start site (TSS) have been shown to influence promoter activity [10]. In addition, nucleosome-bound DNA shows ...
protein-coding target genes, and (vi) TSS oftrans-encoded sRNAs (sTSS) are located in intergenic regions (IGR) and within a defined distance from neighboring genes. Figures1b and1c give an overview of the location and number of TSS in each category, which are discussed in more detail ...
Through inhibiting bHLH proteins such as E, the Id proteins play critical roles in cell differentiation and development in mammals (Ruzinova and Benezra, 2003; Kee, 2009). An Arabidopsis HLH protein has been found to interact with and inhibit a bHLH transcription factor involved in light ...
How cells adopt different identities has long fascinated biologists. Signal transduction in response to environmental cues results in the activation of transcription factors that determine the gene-expression program characteristic of each cell type. Tec