Where in the cell is mRNA translated into proteins? What is the location of DNA in the cell? What does the transcription of cells mean in cellular biology? Transcription happens (in the nucleus/out of the nucleus). Where does RNA synthesis in eukaryotes occur? What is the point of transcri...
As CG dinucleotides in the first exon and intron sometimes show to have equally important biological consequences, the location of the Translational Start Site (and the start codon and CDS—coding sequence) is crucial as well. The TSS can either be experimentally validated or predicted. Some genes...
How cells adopt different identities has long fascinated biologists. Signal transduction in response to environmental cues results in the activation of transcription factors that determine the gene-expression program characteristic of each cell type. Tec
Cell 162, 328–337 (2015). Article CAS PubMed PubMed Central Google Scholar Slager, J. & Veening, J.-W. Hard-wired control of bacterial processes by chromosomal gene location. Trends Microbiol. 24, 788–800 (2016). Article CAS PubMed PubMed Central Google Scholar Peterson, J. R.,...
Poly(dA:dT) tracts are often found in the nucleosome-depleted regions that demarcate eukaryotic core promoters [2, 3, 5] and their length and location relative to the transcription start site (TSS) have been shown to influence promoter activity [10]. In addition, nucleosome-bound DNA shows ...
Induction of mouse germ-cell fate by transcription factors in vitro. The germ-cell lineage ensures the continuity of life through the generation of male and female gametes, which unite to form a totipotent zygote. We have pr... F Nakaki,K Hayashi,H Ohta,... - 《Nature》 被引量: 250发...
Marine bacteria transform DMSP via two competing pathways with considerably different biogeochemical implications: demethylation channels sulfur into the microbial food web, whereas cleavage releases sulfur into the atmosphere. Here, we present single-cell measurements of the expression of these two pathways...
(Z and W), where 41 TFs were located in Z chromosome but only 6 in W chromosome. The fact that TFs were abundant in the left hemisphere suggests that their location in the genome was not random. Then, to explore the different contributions of TFs in different stages of early embryonic ...
With the accumulation of increasing omics data, a key goal of systems biology is to construct networks at different cellular levels to investigate cellular machinery of the cell. However, there is currently no satisfactory method to construct an integrat
Objective To study the role of NF-κB in regulating osteopontin mRNA over expression. Methods Bovine serum Albumin (BSA) wsa added in Cultured renal tubular cell and PDTC plus Cultured renal tubular cell which were incubed for half an hour, respectively, NF-κB activity and OPN mRNA expression...