The eukaryotic nucleus harbors genomic DNA, which is tens of thousands of times greater in linear size than thenuclear diameter. Its high condensation is due to DNA packaging in chromatin, and DNA wrapping around nucleosomalglobules is a key step in the process. A histone octamer, which forms ...
Exosome complex and pervasive transcription in eukaryotic genomes Exosome complex is widely conserved, functionally versatile, and essential constituent of the machinery regulating gene expression in the nucleus as well a... D Belostotsky - 《Current Opinion in Cell Biology》 被引量: 87发表: 2009年...
Here, authors create droplet-in-droplet artificial cells and demonstrate the separation of transcription and translation, akin to the nucleus and cytosol of eukaryotic cells. Kanji Tomohara Yoshihiro Minagawa Hiroyuki Noji ResearchOpen Access24 Jan 2025 Nature Communications Volume: 16, P: 627 Motif...
In addition, this reduction occurs also for GFP proteins that translocate into the cell nucleus by passive diffusion. Finally, our results suggest that cell morphology modulates the protein nuclear import through a partition of the nuclear envelope (NE) surface. Results Spatial organization of focal ...
Gene transcription occurs in both eukaryotic and cells. A eukaryotic cell has a nucleus that separates the processes of transcription and . Eukaryotic transcription occurs within the nucleus where DNA is packaged into and higher order structures. The complexity of the eukaryotic genome necessitates a ...
In nonstimulated cells, NF-kappa B resides in the cytoplasm in an inactive complex with the inhibitor I kappa B. Pathogenic stimuli cause release of I kappa B and allow NF-kappa B to enter the nucleus, bind to DNA control elements and, thereby, induce the synthesis of mRNA. A puzzling ...
JAK2 phosphorylation, which then activates STAT, also by phosphorylation. Activated STAT then dimerizes, translocates to the hematopoietic cell nucleus, binds DNA, and promotes transcription of genes forhematopoiesis. Alteration of JAK2, such as a V617F mutation, results in a constitutively active ...
CELL nucleiEUKARYOTIC cellsDNA-protein interactionsBINDING sitesThere are two physical processes that influence the spatial distribution of transcription factor molecules entering the nucleus of a eukaryotic cell, the binding to genomic DNA and the diffusion throughout the nuclear volume...
With the genes bound in a nucleus, the eukaryotic cell must be able to transport its mRNA to the cytoplasm and must protect its mRNA from degrading before it is translated. Eukaryotes also employ three different polymerases that each transcribe a different subset of genes. Eukaryotic mRNAs are ...
The spatial organization of DNA in the cell nucleus is an emerging key contributor to genomic function. We developed 4C technology (chromosome conformation... A Kashyap,N Kumar,P Kaushik - 《Nature Genetics》 被引量: 379发表: 2006年 Antimicrobial activities of piperacillin-tazobactam against Haemoph...