Regulation of Globin Gene Expression in Erythroid Cells Study of globin gene regulation has served as a useful paradigm for cell-specific and developmental control of transcription in higher eukaryotic cells. Re... Stuart,H.,Orkin - 《Eur J Biochem》 被引量: 66发表: 2008年 Critical Reviews in...
RNA polymerase by itself cannot initiate transcription in eukaryotic cells. There are two types of transcription factors that regulate eukaryotic transcription: General (or basal) transcription factors bind to the core promoter region to assist with the binding of RNA polymerase. Specific transcription ...
We performed subcellular compartment fractionation (whole cell, nucleus and cytosol) before RNA isolation in 15 cell lines (Supplementary Table 1) to interrogate deeply the human transcriptome. For the K562 cell line, we also performed additional nuclear subfractionation into chromatin, nucleoplasm and ...
Research Highlights20 Dec 2024 Cell Research P: 1-2 One-carbon footprint in B cells Dynamic metabolic signatures underpin B cell function throughout development, maturation and differentiation. Germinal center B cells rely on MTHFD2-driven one-carbon metabolism that is dependent on antioxidant ava...
Eukaryotic transcription is dependent on several sequence and structural features. First, actively transcribing genes have a “looser,” more accessible chromatin structure. The nucleosomes are not as condensed as in other forms of chromatin, especially heterochromatin, and they often do not contain his...
A eukaryotic(真核)cell has( ) A. One copy of each ribosomal transcription unit. B. Thousands of copies of the 5S rRNA gene. C. Two copies of each gene for rRNA and ribosomal proteins. D. Two copies of each gene for rRNA and one copy of each ribosomal protein E. ene. 相关知识点...
Eukaryotic transcription initiation requires the assembly of general transcription factors into a pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the transcription start site. The molecular mechanism and function of this assembly have remained elusive due to lac...
NfXB: An Oxidative Stress Responsive Transcription Factor Of Eukaryotic Cells (A Review.) Free Radical Res 来自 ResearchGate 喜欢 0 阅读量: 134 作者:R Schreck,K Albermann,PA Baeuerle 摘要: NF-kappa B is a multiprotein complex that can activate a great variety of genes involved in early ...
Drosophila tRNA genes form stable transcription complexes in vitro, as we have demonstrated by kinetic analyses of transcription experiments in Drosophila Kc cell extracts. tRNA genes added to transcriptionally active cell-free extracts rapidly and stably sequester a transcription factor, inhibiting transcrip...
Eukaryotic transcription factors (TF) function by binding to short 6-10bp DNA recognition sites located near their target genes, which are scattered through vast genomes. Such process surmounts enormous specificity, efficiency and celerity challenges using a molecular mechanism that remains poorly understo...