In an attempt to discover transcription factor binding motifs (TFBMs) in P. falciparum , we considered two approaches. In the first approach, gene expression data from asexual intraerythrocytic developmental cycle generated every hour for 48 hour post-infection were fed into the ISA (Iterative ...
Comprehensive Human Transcription Factor Binding Site Map for Combinatory Binding Motifs Discovery.To know the map between transcription factors (TFs) and their binding sites is essential to reverse engineer the regulation process. Only about 10%-20% of the transcription factor binding motifs (TFBMs)...
A sequence motif is a short recurring pattern with biological significance such as a DNA-recognition sequence for a transcription factor (TF), an mRNA splicing signal, or a functional region of a protein domain. Many high-throughput experimental approaches and computational tools have been developed...
Transcription factor binding motifs associated with hDEGs in brain cells An important driver of environmentally-induced changes in gene expression is changes in transcription factor (TF) binding at enhancers. We therefore performed a motif enrichment analysis at enhancers near hDEGs for all brain cell ...
comprising more than 70 DNA-binding domain types [1]. Studies on TF-binding sites have revealed that TFs do not bind to a single sequence, but rather to a distinct set of similar DNA sequences. Such specific sequence patterns are known as DNA-binding motifs. These motifs can be elucidated...
Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs is a crucial problem in computational biology and includes the subtask of predicting the location of known TFBS motifs in a given DN...
The propensity of transcription factors (TFs) to be inhibited from binding motifs due to reversible chromatin features such as modification of DNA (CpG methylation) or presence and actions of chromatin proteins (such as nucleosomes). Methylation-sensitive Refers to transcription factor (TF) motifs th...
Transcription factor binding sites (TFBSs) are most commonly characterized by the nucleotide preferences at each position of the DNA target. Whereas these sequence motifs are quite accurate descriptions of DNA binding specificities of transcription factors (TFs), proteins recognize DNA as a three-dimens...
Studies of gene regulation often utilize genome-wide predictions of transcription factor (TF) binding sites. Most existing prediction methods are based on sequence information alone, ignoring biological contexts such as developmental stages and tissue types. Experimental methods to studyin vivobinding, inc...
Transcription factor binding sites (TFBSs) are most commonly characterized by the nucleotide preferences at each position of the DNA target. Whereas these sequence motifs are quite accurate descriptions of DNA binding specificities of transcription factors (TFs), proteins recognize DNA as a three-...