FOXM1 is a master factor involved in G1/S and G2/M cell cycle transition and M phase progression. It has been linked to normal chromosomal stability and segregation during mitosis [43]. FOXM1 has been associated with cellular senescence, stem cell-like self-renewal, cell differentiation and...
The forkhead box (FOX) transcription factor family consists of an evolutionarily conserved group of transcriptional regulators engaged in numerous functions during development and adult life; their dysfunction has been associated with human diseases [36,37,38,39,40,41,42]. SeveralFOXgene subgroup trans...
A prominent method to generate T cells is an in vitro system via co-culture of either mouse or human hematopoietic stem/progenitors (HSPCs) with stromal cell lines expressing the Notch ligand, such as OP9-DL1/DL4 or 3D-based MS5-hDLL1/4.1,2,3Despite the great contribution of this appro...
The mitochondrial Transcription Factor A (TFAM) is a key component of mtDNA transcription and is the main factor for nucleoid compaction and mtDNA maintenance26–29. TFAM is a member of the High-Mobility Group (HMG)-box protein superfamily. HMG-box proteins are abundant, essential, ubiquitously ...
Increased expression of the Zn-finger transcription factor BTEB1 in human endometrial cells is correlated with distinct cell phenotype, gene expression patterns, and proliferative responsiveness to serum and TGF-β1BTEB1Cell growthEndometrial carcinoma...
Systematic investigation of transcription factor activity in the context of chromatin using massively parallel binding and expression assays Mol. Cell, 65 (2017) 604-617 e606 Google Scholar [12] B.B. Maricque, J.D. Dougherty, B.A. Cohen A genome-integrated massively parallel reporter assay reve...
Conserved domain database CES: CESTA CIB1: Cryptochrome-interacting basic/helix-loop-helix 1 CIL2: CIB1 like protein 2 CITF1: Cu-deficiency induced transcription factor 1 DYT1: Dysfunctional tapetum 1 EGL3: Enhancer of glabra 3 FBH1: Flowering bHLH 1...
lated transcription factor; the apo-forms of WhiB1 also bind DNA [5–7]. The ability to sense and respond to NO is an important adaptive feature of many bacterial pathogens because it is a crucial component of the host innate immune response [8]. The preferred ...
sarcoma viral oncogene homolog; MAPK1 Mitogen-activated protein kinase 1; MAPK3 Mitogen-activated protein kinase 3; MAPK14 Mitogen-activated protein kinase 14; CSFIR Colony stimulating factor 1 receptor; ETS1:V-ets erythroblastosis virus E26 oncogene homolog 1 (avian); SP1Sp1transcriptionfactor; ...
In this present work, we identify and characterize a transcription factor i.e. HIC1, which physically interacts with both Bcl11b/CTIP2 and HMGA1 to co-regulate specific subsets of cellular genes and the viral HIV-1 gene. Our results suggest that HIC1 represses Tat dependent HIV-1 ...